Integration method and structure of transdermal drug-delivery microneedle array and soft forming facial mask

Abstract

The invention provides an integration method of a transdermal drug-delivery microneedle array and a soft forming facial mask. The integration method comprises the followings steps that a plurality of sacs are prepared on the soft forming facial mask, and one end of each sac is opened on the surface on one side of the facial mask, while the other end does not penetrate the facial mask but keeps the bottom of the facial mask as a base mask of the facial mask; each sac is internally provided with a microspring and the pedestal of the microspring is combined with the base mask of the facial mask; the microneedle array is embedded in the sacs of the soft forming facial mask in a direction that a needlepoint points downwards at the base mask, and the pedestal of the microneedle array is combined with the top end of the microspring; transdermal drug-delivery liquid medicament is soaked in the soft forming facial mask to circulate freely inside the sacs and the base mask through pore spaces in mask materials; and the pedestal of the microneedle array is pressed to ensure that the needlepoints of microneedles penetrate the base mask and keratodermia. The invention also provides an integration structure of the transdermal drug-delivery microneedle array and the soft forming facial mask. The integration method and structure are particularly suitable for large-area transdermal delivery of polymer medicaments used for facial skin care.

Description

technical field [0001] The invention relates to an integration method and an integration structure of a transdermal drug delivery microneedle array and a soft forming mask. The method and structure are suitable for large-area transdermal delivery of facial skin care polymer drugs. Background technique [0002] The facial covering sheet impregnated with skin care drug ingredients belongs to the category of transdermal drug delivery in terms of drug delivery technology. Epidermal growth factor, transforming growth factor, elastin, collagen, and hyaluronic acid in skin care drugs are mostly polymers, and their transdermal absorption rate is very low due to the barrier function of the stratum corneum. Even with auxiliary means such as ionization penetration and ultrasound, it is still difficult to significantly increase its transdermal absorption rate. [0003] In order to enhance the transdermal absorption rate of polymer drugs, the following method has been proposed: microne...

AI Technical Summary

Problems solved by technology

Due to the small base area of ​​the array, the existing microneedle arrays are manually pulled out from the skin.

However, facial skin care needs to cover a large area of ​​facial skin. At this time, it is not only cumbersome and difficult to use manual needle extraction, but also easily breaks the microneedles.

Broken microneedles remain in the facial skin, which will be very harmful to the skin

Hollow microneedles are especially prone to breakage due to their lower mechanical strength than solid microneedles, and hollow tubes are prone to blockage during penetration into skin tissue

[0007] 3. The procedure is cumbersome

figure 1 Indicates that in the prior art, the microneedle body 111 always protrudes out of the soft base 110, which easily causes the microneedle to break

Broken microneedles lodged in the skin 112 will be detrimental to the skin

[0010] (2) The problem of pulling out the needle after the microneedle penetrates the skin is not solved

Therefore, there is still a potential danger of microneedle breakage caused by manual needle removal

[0011] (3) The manufacturing process is cumbersome

It requires ion implantation, coating of soft materials and other processes, and then needs to install the drug storage behind, and the process is relatively cumbersome

Images