Combination chemical chip with quantitative uniform sampling on the back and its application method
A combinatorial chemistry and sample injection technology, applied in the field of analytical chemistry, can solve problems such as difficulty and high equipment requirements, and achieve the effect of reasonable structure, structural form and integration, and uniform distribution
Active Publication Date: 2020-09-04
SHAANXI NORMAL UNIV
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Problems solved by technology
Although it is convenient in operation, its operation has certain difficulty and high equipment requirements
Method used
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Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0054] Using filter paper as a flat substrate, prepare a high-throughput combination chemical chip according to Example 2 of the 201610700220.4 patent; use a hydrophilic non-woven fabric of the same size as the flat substrate as the pre-dispersed sample injection layer; use a slightly larger substrate The PVC film is used as the partition and impermeable layer. Prepare a transparent jig, refer to the back image 3 The structure, the front surface is uniform and transparent, it is a transparent plastic frame in mass production. Use this transparent fixture, refer to figure 1 Sequence, assemble the chip.
Embodiment 2
[0056] Perform Example 1 and replace the filter paper with a mixed cellulose filter membrane with a pore size of 5 microns.
Embodiment 3
[0058] Execute Example 1, and replace the hydrophilic non-woven fabric with ultra-thin sponge as the pre-dispersed sample injection layer 3.
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The invention discloses a combined chemical chip with quantitative and uniform sample introduction on a back surface and a use method thereof. The device comprises a planar substrate adopting a permeable material and used for bearing active reactants, a pre-dispersed sample introduction layer sheet adopting a permeable material and used for receiving a liquid substance to be measured, and a separating impermeable layer sheet adopting an impermeable material and capable of being extracted out from a position between the planar substrate and the pre-dispersed sample introduction layer sheet, wherein the area of the separating impermeable layer sheet is equal to or slightly larger than that of the planar substrate of the chemical chip, and the separating impermeable layer sheet is used for separating the planar substrate and the pre-dispersed sample introduction layer sheet. The method includes the steps: 1, according to the specifications of the combined chemical chip, a certain amount of the liquid substance to be measured is quantitatively measured; 2, the chip is inverted, and the quantitative liquid substance to be measured is dispersed and dropwise added on the pre-dispersed sample introduction layer sheet; 3, after the liquid substance is dispersed evenly, the separating impermeable layer sheet is extracted out; and 4, after the liquid to be measured is permeated evenly into the front face, bearing active reactants or sensitive materials of the reaction unit, on the planar substrate, and an obtained reaction pattern is observed or shot.
Description
Technical field [0001] The invention relates to analytical chemistry, in particular to a combined chemistry chip with quantitative and uniform sample injection on the back and a use method thereof. Background technique [0002] The high-throughput combinatorial chemistry chip is a very efficient type of complex chemical system analysis technology, especially after combining combinatorial chemistry technology and artificial intelligence big data analysis technology, its application field and the depth of problem solving have been significantly improved. The combinatorial chemical chip mentioned here refers to a plurality of chemical reaction micro-units with different properties distributed on a flat substrate. The combination here means that many different chemical reaction points are arranged together, and each reaction point is independent to a certain extent. In recent years, there have been some scientific researches in this area. For example, in 2017, X Yan, YZheng, J Gao ...
Claims
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IPC IPC(8): G01N21/84G01N21/01
CPCG01N21/01G01N21/84G01N2021/0112
Inventor 李剑超李蕴王尧段倩囡郑允允晏幸
Owner SHAANXI NORMAL UNIV