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Combined chemical chip with quantitative and uniform sample introduction on back surface and use method thereof

A technology of combinatorial chemistry and sample injection, applied in the field of analytical chemistry, it can solve problems such as high equipment requirements and difficulty, and achieve the effect of structural form and integration, reasonable structure and good guiding effect.

Active Publication Date: 2018-08-03
SHAANXI NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although it is convenient in operation, its operation has certain difficulty and high equipment requirements

Method used

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  • Combined chemical chip with quantitative and uniform sample introduction on back surface and use method thereof
  • Combined chemical chip with quantitative and uniform sample introduction on back surface and use method thereof
  • Combined chemical chip with quantitative and uniform sample introduction on back surface and use method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0054] Using filter paper as a planar substrate, prepare a high-throughput combined chemical chip according to Example 2 of the 201610700220.4 patent; use a hydrophilic non-woven fabric of the same size as the planar substrate as a pre-dispersed sampling layer; use a slightly larger planar substrate The PVC film is used as a separate anti-seepage layer. Prepare a transparent fixture, back referenced image 3 Structural, homogeneous transparent front, frame in clear plastic when mass-produced. Using this clear jig, refer to figure 1 Sequentially, assemble the chips.

Embodiment 2

[0056] Execute Example 1, and replace the filter paper therein with a mixed cellulose filter membrane with a pore size of 5 microns.

Embodiment 3

[0058] Execute Example 1, and replace the hydrophilic non-woven fabric with an ultra-thin sponge as the pre-dispersed sampling layer 3 .

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PUM

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Abstract

The invention discloses a combined chemical chip with quantitative and uniform sample introduction on a back surface and a use method thereof. The device comprises a planar substrate adopting a permeable material and used for bearing active reactants, a pre-dispersed sample introduction layer sheet adopting a permeable material and used for receiving a liquid substance to be measured, and a separating impermeable layer sheet adopting an impermeable material and capable of being extracted out from a position between the planar substrate and the pre-dispersed sample introduction layer sheet, wherein the area of the separating impermeable layer sheet is equal to or slightly larger than that of the planar substrate of the chemical chip, and the separating impermeable layer sheet is used for separating the planar substrate and the pre-dispersed sample introduction layer sheet. The method includes the steps: 1, according to the specifications of the combined chemical chip, a certain amount of the liquid substance to be measured is quantitatively measured; 2, the chip is inverted, and the quantitative liquid substance to be measured is dispersed and dropwise added on the pre-dispersed sample introduction layer sheet; 3, after the liquid substance is dispersed evenly, the separating impermeable layer sheet is extracted out; and 4, after the liquid to be measured is permeated evenly into the front face, bearing active reactants or sensitive materials of the reaction unit, on the planar substrate, and an obtained reaction pattern is observed or shot.

Description

technical field [0001] The invention relates to analytical chemistry, in particular to a combined chemical chip with quantitative and uniform sample injection on the back and its application method. Background technique [0002] High-throughput combinatorial chemistry chip is a kind of very efficient complex chemical system analysis technology. Especially after combining combinatorial chemistry technology and artificial intelligence big data analysis technology, its application fields and depth of problem solving have been significantly improved. The combined chemical chip mentioned here refers to a plurality of chemical reaction micro-units with different properties distributed on a flat substrate. Combination here means that many different chemical reaction points are arranged together, and each reaction point is independent to a certain extent. In recent years, some scientific research work has been carried out to explore this aspect. For example, "A simple strategy for...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/84G01N21/01
CPCG01N21/01G01N21/84G01N2021/0112
Inventor 李剑超李蕴王尧段倩囡郑允允晏幸
Owner SHAANXI NORMAL UNIV