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Application of Chinese medicinal composition in preparing medicament for treating chronic glomerulonephritis

A technology of glomerulonephritis and composition, which is applied in the application field of traditional Chinese medicine composition in the preparation of drugs for treating chronic glomerulonephritis, and can solve the problems of patients with unknown etiology, no clear relationship, and no definite association

Active Publication Date: 2010-01-06
BEIJING YILING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Chronic nephritis is a group of glomerular diseases mainly caused by chronic glomerular lesions with multiple etiologies. However, the etiology of most patients is unknown and has no clear relationship with streptococcal infection. According to statistics, only 15-20% of patients have changed from acute glomerulonephritis However, most patients with chronic nephritis have no history of acute nephritis. Therefore, it is currently believed that there is no definite relationship between chronic glomerulonephritis and acute nephritis. It may be caused by various bacterial, viral or protozoan infections through immune mechanisms, inflammatory mediators Factors and non-immune mechanisms cause the disease

Method used

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  • Application of Chinese medicinal composition in preparing medicament for treating chronic glomerulonephritis
  • Application of Chinese medicinal composition in preparing medicament for treating chronic glomerulonephritis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0080] Embodiment 1: the preparation of medicine capsule of the present invention

[0081] prescription:

[0082] Astragalus 70g Talc 14g Prunella vulgaris 21g Ligustrum lucidum 14g

[0083] 21 grams of lychee core, 2.1 grams of amber, 2.8 grams of cinnamon, and 7 grams of cork

[0084] Preparation:

[0085] (1), take by weighing Chinese herbal medicine according to prescription quantity, net select respectively, pulverize;

[0086] (2), get Radix Astragali and Cortex Phellodendri, add 60% ethanol, heat and reflux to extract 2 times, add 10 times the amount for the first time, extract for 2 hours, add 8 times the amount for the second time, extract for 1 hour, filter the extract, merge, After the ethanol is recovered under reduced pressure, it is concentrated into a clear paste with a relative density of 1.20-1.25, put into a vacuum drying oven, and dried under reduced pressure at a temperature of 65°C and a vacuum degree of 0.05Mpa, and the dry paste is used for later use;...

Embodiment 2

[0093] Embodiment 2: the preparation of pharmaceutical tablet of the present invention

[0094] prescription:

[0095] Astragalus 30 grams, talc 7 grams, Prunella vulgaris 10 grams, Ligustrum lucidum 7 grams

[0096] 10 grams of lychee core, 1 gram of amber, 1.5 grams of cinnamon, 3 grams of cork

[0097] Preparation:

[0098] (1), take by weighing Chinese herbal medicine according to prescription quantity, net select respectively, pulverize;

[0099] (2), get Radix Astragali and Cortex Phellodendri, add 60% ethanol, heat and reflux to extract 2 times, add 9 times the amount for the first time, extract for 3 hours, add 8 times the amount for the second time, extract for 1.5 hours, filter the extract, merge, After the ethanol is recovered under reduced pressure, it is concentrated into a clear paste with a relative density of 1.20-1.25 for subsequent use;

[0100] (3), get Ligustrum lucidum, add 7 times the amount of 80% ethanol, heat and reflux to extract 2 times, the time...

Embodiment 3

[0105] Embodiment 3: the preparation of medicament oral liquid of the present invention

[0106] prescription:

[0107]Astragalus 34g Talc 12g Prunella vulgaris 19g Ligustrum lucidum 18g

[0108] 25 grams of lychee core, 2.5 grams of amber, 4.5 grams of cinnamon, and 13 grams of cork

[0109] Preparation method: make oral liquid according to conventional preparation methods.

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Abstract

The invention discloses application of a Chinese medicinal composition in preparing a medicament for treating chronic glomerulonephritis. The Chinese medicinal composition consists of eight gouts of Chinese medicaments such as astragalus root, steatite, selfheal, and the like. The medicinal composition has the efficacies of promoting qi transformation, promoting diuresis and softening hardness to dissipate stagnation. The clinical research shows that the Chinese medicinal composition can effectively treat the chronic glomerulonephritis.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine composition, in particular to an application of a traditional Chinese medicine composition in preparing a medicine for treating chronic glomerulonephritis. Background technique [0002] Chronic glomerulonephritis (CGN) refers to a group of diffuse or focal inflammatory changes in bilateral glomeruli of different pathological types caused by various etiologies, clinical onset is insidious, the course of the disease is long, and the disease progresses slowly. Generic term for primary glomerular diseases. [0003] Chronic nephritis is a group of glomerular diseases mainly caused by chronic glomerular lesions with multiple etiologies. However, the etiology of most patients is unknown and has no clear relationship with streptococcal infection. According to statistics, only 15-20% of patients have changed from acute glomerulonephritis However, most patients with chronic nephritis h...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61K9/48A61K9/20A61K9/10A61P13/12A61K33/12A61K35/10
Inventor 李向军安军永王超郑立发
Owner BEIJING YILING PHARMA
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