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Medicinal preparation for treating colpitis and method for preparing same

A technology for pharmaceutical preparations and vaginitis, applied in the field of pharmaceutical preparations and their preparation, can solve the problems of no products on the market, and achieve the effects of non-allergic, stable pharmaceutical preparations, easy melting and absorption

Active Publication Date: 2010-01-27
高瑞耀业(北京)科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There is no report on the formulation of ornidazole effervescent suppository in China, and no product is on the market

Method used

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  • Medicinal preparation for treating colpitis and method for preparing same
  • Medicinal preparation for treating colpitis and method for preparing same
  • Medicinal preparation for treating colpitis and method for preparing same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0134] Embodiment 1: the preparation of ornidazole effervescent suppository

[0135] Ornidazole 500g

[0136] Sodium bicarbonate 165g

[0137] Citric Acid Monohydrate 165g

[0138] Semi-synthetic fatty acid glycerides 1280g

[0139] Polysorbate 80 88g;

[0140] Dry ornidazole, sodium bicarbonate and citric acid monohydrate at 60°C, pass through 80-mesh sieve respectively, and set aside; coat the mold with liquid paraffin no higher than 1mm, set aside; put 1280g of semi-synthetic fatty acid glyceride in a water bath Melt at 60°C, add 88g of polysorbate 80, and stir evenly; keep warm at 60°C, add 500g of ornidazole, 165g of sodium bicarbonate and 165g of citric acid monohydrate, stir evenly, and fill the mold while it is hot; After the liquid medicine is cooled and shaped, the mold is opened to take out the medicine pieces, and 1000 ornidazole effervescent suppositories are obtained.

Embodiment 2

[0141] Embodiment 2: the preparation of ornidazole effervescent suppository

[0142] Ornidazole 450g

[0143] Sodium bicarbonate 120g

[0144] Citric Acid Monohydrate 120g

[0145] Semi-synthetic fatty acid glycerides 1200g

[0146] Polysorbate 80 60g;

[0147] Dry ornidazole, sodium bicarbonate and citric acid monohydrate at 55°C, pass through a 70-mesh sieve respectively, and set aside; coat the mold with liquid paraffin no higher than 1mm, set aside; put 1200g of semi-synthetic fatty acid glyceride Melt in a water bath at 55°C, add 60g of polysorbate 80, stir evenly, keep warm at 55°C, add 450g of ornidazole, 120g of sodium bicarbonate and 120g of citric acid monohydrate, stir evenly, and pour it into a mold while it is hot After the liquid medicine is cooled and shaped, the mold is opened to take out the medicine pieces, and 1000 ornidazole effervescent suppositories are obtained.

Embodiment 3

[0148] Embodiment 3: the preparation of ornidazole effervescent suppository

[0149] Ornidazole 550g

[0150] Sodium bicarbonate 200g

[0151] Citric Acid Monohydrate 200g

[0152] Semi-synthetic fatty acid glycerides 1350g

[0153] Polysorbate 80 100g;

[0154] Dry ornidazole, sodium bicarbonate and citric acid monohydrate at 65°C, pass through a 90-mesh sieve respectively, and set aside; coat the mold with liquid paraffin no higher than 1 mm, set aside; 1350 parts by weight of semi-synthetic fatty acid Melt the glyceride in a water bath at 65°C, add 100 parts by weight of polysorbate 80, stir evenly, keep warm at 65°C, add 550 parts by weight of ornidazole, 200 parts by weight of sodium bicarbonate and 200 parts by weight of lemon monohydrate acid, stirred evenly, and molded while hot; after the liquid medicine was cooled and formed, the mold was opened to take out the medicine pieces, and 1000 ornidazole effervescent suppositories were obtained.

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Abstract

The invention discloses a medicinal preparation for treating colpitis and a method for preparing the same. The medicinal preparation consists of ornidazole, sodium bicarbonate, Citric acid monohydrate, semi-synthetic fatty glyceride and polysorbate80. For the effervescent suppository of the invention, the ornidazole is added with a foaming agent, so that the effervescent effect can be generated to accelerate the dissolution of the suppository and the release of the medicament when the effervescent suppository is used. The medicinal preparation has the advantages of the effervescent preparation as well as characteristics of the suppository; the medicament can be dissolved and absorbed more easily; and the effervescent suppository is the solid preparation and contributes to the storage of the medicaments which have active properties and are easily oxidized and reduced. Therefore, the medicinal preparation is actively meaningful for actual clinical application.

Description

technical field [0001] The invention relates to a medicinal preparation and a preparation method thereof, in particular to a medicinal preparation for treating vaginitis and a preparation method thereof. Background technique [0002] Vaginitis is a common and frequently-occurring disease in gynecology. According to literature reports, the anaerobic infection rate of female genitalia is as high as 60-80%. According to reports, metronidazole and tinidazole have mutagenic and teratogenic effects in animal experiments, and have adverse interactions with ethanol, such as nausea, vomiting, dyspnea, chest pain, chest tightness, confusion and orthostatic hypotension, etc. Nitazole has no mutagenic and teratogenic effects, and has no adverse interaction with ethanol. Topical ornidazole is more effective than metronidazole and tinidazole. In terms of anti-anaerobic infection, the minimum bacteriostatic concentration and minimum bactericidal concentration of ornidazole are lower than...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4164A61K47/04A61K47/12A61K47/14A61K47/34A61P15/02A61K47/26
Inventor 薛泉党艳丽于烨
Owner 高瑞耀业(北京)科技有限公司
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