Glutathione derivative and anti-tumor medical application thereof
A glutathione and anti-tumor drug technology, applied in anti-tumor drugs, tripeptide components, drug combinations, etc., can solve the problem of low activity of GlxII
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[0018] Synthetic Irreversible Inhibitors of GlxI
[0019] The synthetic pathways of S-(bromoacetamidoalanylmethyl)glutathione (BPSG) and S-(bromoacetamidobutanylmethyl)glutathione (BBSG) are as follows:
[0020]
[0021] Dibromoacetyl(1,3)propylenediamine
[0022] Put 50 milliliters of chloroform and 1,3-propanediamine (13mmol) in the flask of 100 milliliters, then put into ice bath and wait for cooling, slowly drop bromoacetyl chloride (1.03g, 26mmol) under stirring condition , Continue to stir for half an hour after dripping. The solvent was evaporated to dryness with a rotary evaporator under reduced pressure to obtain a light brown crude product. Yield: 90%. 1 H NMR 300MHz (CDCl 3 , TMS) δ3.80 (4H, s, -C(O)CH 2 Br), 3.25 (4H, t, J=6.25Hz, -NHCH 2 CH 2 -), 1.85 (2H, p, J=6.25Hz, -NHCH 2 CH 2 -).ESI MS: (M(Br 79 )+H + ) 314.93. Dibromoacetyl (1,4) butanediamine
[0023] The synthetic pathway of this compound is roughly the same as that of dibromoacetyl (1,3) p...
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