Natural activator of soluble guanylate cyclase
A guanylate cyclase, soluble technology, applied in the fields of biochemistry and medicinal chemistry, can solve the problems of inconvenient use, individual differences, and large toxic and side effects
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[0013] (1) Purification, activity determination and purity identification of bovine lung soluble guanylyl cyclase were performed using our established method (Li zhengqiang et al Biochemistry (2005) 44: 939).
[0014] (2) with purified soluble guanylate cyclase and 3 The H-GTP bioassay technology platform screens out the active ingredients in plant medicines with activating effects.
[0015] (3) Separating the components of the screened botanical drugs by category, and then screening to determine the chemical classification of the compound, and use computer-aided optimization technology to determine the structure of YC-1 and BAY chemically synthesized in vitro using combinatorial chemistry methods Comparative analysis and simulation.
[0016] (4) Separation and screening of a single compound.
[0017] (5) The study on the synergistic activation of soluble guanylate cyclase by activators (compounds) and carbon monoxide, Km, Vm determination.
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