Anti-cancer medicine both for diagnosing and treating cancer

一种抗癌药物、癌症的技术，应用在抗肿瘤药、药物组合、药物输送等方向，能够解决损失率高等问题，达到小副作用、高抗癌作用、降低心脏毒性副作用的效果

Inactive Publication Date: 2010-03-24
YOULCHON CHEM
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Use of large amounts of chemotherapeutics, resulting in high loss rates during formulation of drug delivery vehicles with chemotherapeutics or other mixing processes

Method used

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  • Anti-cancer medicine both for diagnosing and treating cancer
  • Anti-cancer medicine both for diagnosing and treating cancer
  • Anti-cancer medicine both for diagnosing and treating cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment approach

[0083] Hereinafter, the present invention will be described more specifically with reference to preferred embodiments. It will be readily understood by those skilled in the art that the embodiments are provided to illustrate the present invention, not to limit the present invention.

preparation Embodiment 1

[0085]

[0086] PEO-TMA-FA of Chemical Formula 2 was prepared according to the following method.

[0087] [chemical formula 2]

[0088]

[0089] (1) Polymerization of PEO

[0090] First, the PEO is polymerized as shown in Reaction 1.

[0091] [reaction 1]

[0092]

[0093] As shown in Reaction 1, the various reactants were placed in a 1 L capacity round heat-resistant glass flask under high vacuum. Then, the flask was connected to a vacuum line to completely remove the air. Thereinto was injected n-butyllithium (12 mmol) with a syringe under an argon flow. The temperature of the reactor was lowered to -78°C using a dry ice / isopropanol bath instead of a water bath, and the argon in the reactor was completely evacuated using a vacuum pump. Another 300 mL of refined benzene was distilled off and then injected into the reactor. The temperature of the reactor was gradually raised to room temperature to completely dissolve and reduce the benzene in the solution containin...

preparation Embodiment 2

[0101]

[0102] mPEG-TMA-FA represented by Chemical Formula 3 was prepared as follows.

[0103] [chemical formula 3]

[0104]

[0105] (1) Modification of mPEG

[0106] mPEG was modified according to Reaction 3.

[0107] [Reaction 3]

[0108]

[0109] 0.01 mol of methoxy-polyethylene glycol (molecular weight: 5,000 g / mol, Aldrich: mPEG) was placed in a round-bottom heat-resistant glass flask with a capacity of 2 L, which was then inserted into a vacuum line to remove air completely and carried out dry. 1 L of benzene was distilled off to dissolve mPEG, and its temperature was lowered using an ice-water bath. Thereinto was slowly injected n-butyllithium (30 mL) using a syringe under an argon flow. After injection, the temperature was slowly raised to 30°C. After reacting for 48 hours, it was observed that the colorless color had changed to yellow, and a small amount of methanol was distilled off and added thereto, and then made to contact with air, and the reactio...

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Abstract

Disclosed is an anti-cancer medicine comprising a chain end functionalized polymer, a contrast material such as iron oxide and a chemother apeut i c agent such as doxorubicin or pharmaceutically acceptable salts thereof. The anti-cancer medicine performs diagnosis and treatment of cancer at the same time, remarkably reduces a cardiotoxic side effect of the doxorubicin and has an excellent targeting function to the cancer part to considerably increase the anti-cancer effect. At the same time, the anti-cancer medicine is provided as MRI contrast medium which can diagnose the cancer and monitor aprogress of the disease. In particular, the anti-cancer medicine is disclosed which is superior to the diagnosis and treatment of the solid cancer and can effectively perform the diagnosis and treatment of the metastatic cancer as well as the primary cancer at the same time.

Description

technical field [0001] The invention relates to a polymer micelle type contrast medium and an anticancer drug for diagnosing and treating cancer. More specifically, the present invention relates to micellar nanoparticle contrast media and anticancer drugs, which include chemotherapeutic agents, such as contrast materials such as chain-end functionalized polymers and iron oxides, and doxorubicin and pharmaceutically acceptable salts thereof , which is capable of diagnosing and effectively treating cancer while reducing side effects. Background technique [0002] In general, polymers used as transporters for drug delivery into an organism need to be biosynthesized or biodegraded. For example, a polymer such as PLGA is degraded into such as lactic acid and glycolic acid in an organism so that it has no harmful effect on the organism. Therefore, when the drug delivery carrier is made of a biodegradable polymer, sustained release (emission) of various drugs can be expected. In...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/4985
CPCA61K47/488A61K9/0019A61K49/1809A61K31/00A61K31/704A61K47/48215A61K9/1075A61K47/48107A61K31/787A61K47/551A61K47/60A61K47/6907A61P35/00A61P35/04B82B3/00H01J9/00
Inventor 辛东崙金长燮
Owner YOULCHON CHEM
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