Use and preparation method of vaginal thermosensitive gel
A temperature-sensitive gel and temperature-sensitive gel matrix technology are applied in the fields of polymer materials and preparation to achieve the effects of good fluidity, reduced administration frequency and enhanced therapeutic effect
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Embodiment 1
[0041] Take the temperature-sensitive gel matrix of the present invention, add 0.01% India ink for coloring; take the solid gel of carbomer matrix, add 0.01% India ink coloring as a control group, and inject them into the vagina of mice respectively at 0.5h, 1h, 3h, The mice were killed at 6h, 12h, 16h, and 20h, and the vagina was taken to observe the retention time of the gel in the mice. figure 1 .
[0042] From figure 1 It can be seen that the carbomer-based solid gel is basically emptied after 3 hours of administration, while the temperature-sensitive gel matrix of the present invention can also be observed at 20 hours. Therefore, the residence time in the body is greater than 20 hours, which can achieve once a day treatment aims.
Embodiment 2
[0043] Example 2 Comparative experiment of treating mycoplasma vaginitis with thermosensitive gel for vagina containing 1% turmeric oil and commercially available turmeric oil suppository
[0044] 40 SPF female KM mice were pretreated with hormones, and 30 mice were randomly selected to be inoculated vaginally with Ureaplasma urealyticum (Uu bacterial liquid) every other day, 20ul 2.5×105ccu / ml each time for 7 consecutive days. Construct a mouse model of mycoplasma infection with vaginitis. After successful model building, 10 animals without Uu bacterial liquid were regarded as normal group; 30 animals after inoculation were randomly divided into model group, turmeric oil temperature-sensitive gel group, and turmeric oil suppository group, with 10 animals in each group, administered vaginally. The normal group was given no medication, the model group was given a blank gel matrix, and the zedoary turmeric oil temperature-sensitive gel group and zedoary turmeric oil suppository gro...
Embodiment 3
[0050] Example 3 A comparison experiment on the treatment of fungal vaginitis with a 0.1% vaginal temperature-sensitive gel preparation containing amphotericin B and a commercially available amphotericin B effervescent tablet (0.1%)
[0051] 40 SPF female KM mice, after hormone pretreatment, 30 randomly selected vaginal inoculation of Candida albicans liquid, once every other day, 20 μL of 1×10 each time 8 Cfu / mL, for 7 consecutive days, a mouse model of mold infection with vaginitis was constructed. After successful modeling, 10 animals that were not inoculated with Candida albicans liquid were regarded as the normal group; 30 animals after inoculation were randomly divided into the model group, the amphotericin B temperature-sensitive gel group, and the amphotericin B effervescent tablet group, each with 10 only. Vaginal administration, no administration in the normal group, blank gel matrix in the model group, and corresponding drugs in the amphotericin B temperature-sensitive...
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