New disubstituted phenylpyrrolidines as modulators of cortical catecholaminergic neurotransmission
A technology of pyrrolidine and difluorophenyl, applied in the field of novel disubstituted phenylpyrrolidine and these compounds, can solve the problem of no norepinephrine and dopamine neurotransmission, etc.
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Embodiment 1
[0187] figure 1 .Example 1, 50 μmol / kg subcutaneous striatal amine
[0188] Example 1 (subcutaneous injection) was injected at time point 0. exist figure 1 Values stated in represent percentage of control relative to baseline value. Microdialysis was performed in conscious and freely moving rats. Dopamine = DA; Norepinephrine = NA; Serotonin = 5-HT; Error bars = SEM
[0189] figure 2 .Example 1, 50 μmol / kg subcutaneously p.f. cortical amine
[0190] Example 1 (subcutaneous injection) was injected at time point 0. exist figure 2 Values stated in represent percentage of control relative to baseline value. Microdialysis was performed in conscious and freely moving rats. Dopamine = DA; Norepinephrine = NA; Serotonin = 5-HT; Error bars = SEM
Embodiment 2
[0191] image 3 .Example 2, 50 μmol / kg subcutaneous striatal amine
[0192] Example 2 was injected at time point 0 (subcutaneous injection). exist image 3 Values stated in represent percentage of control relative to baseline value. Microdialysis was performed in conscious and freely moving rats. Dopamine = DA; Norepinephrine = NA; Serotonin = 5-HT; Error bars = SEM
[0193] Figure 4 .Example 2, 50 μmol / kg subcutaneously p.f. cortical amine
[0194] Example 2 was injected at time point 0 (subcutaneous injection). exist Figure 4 Values stated in represent percentage of control relative to baseline value. Microdialysis was performed in conscious and freely moving rats. Dopamine = DA; Norepinephrine = NA; Serotonin = 5-HT; Error bars = SEM
[0195] Figure 5 : Example 3, 50 μmol / kg subcutaneous striatal amine
[0196] Example 3 was injected at time point 0 (subcutaneous injection). exist Figure 5 Values stated in represent percentage of control relati...
Embodiment 5
[0203] Figure 9 .Example 5, 50 μmol / kg subcutaneous striatal amine
[0204] Example 5 was injected at time point 0 (subcutaneous injection). exist Figure 9 Values stated in represent percentage of control relative to baseline value. Microdialysis was performed in conscious and freely moving rats. Dopamine = DA; Norepinephrine = NA; Serotonin = 5-HT; Error bars = SEM
[0205] Figure 10 .Example 5, 50 μmol / kg subcutaneously p.f. cortical amine
[0206] Example 3 was injected at time point 0 (subcutaneous injection). exist Figure 10 Values stated in represent percentage of control relative to baseline value. Microdialysis was performed in conscious and freely moving rats. Dopamine = DA; Norepinephrine = NA; Serotonin = 5-HT; Error bars = SEM
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