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Preparation and application of superparamagnetic carbon nanotube contrast agent

A carbon nanotube and superparamagnetic technology, which is applied in the field of preparation and application of superparamagnetic carbon nanotube contrast agents, can solve problems such as inability to effectively reach diseased tissues, and achieves convenient and accurate diagnosis, low toxicity and good imaging effect. Effect

Inactive Publication Date: 2011-09-14
SHANGHAI NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

After intravenous administration, this contrast agent is mainly cleared by mononuclear macrophages in the body, and cannot effectively reach the diseased tissue to achieve efficient imaging.

Method used

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  • Preparation and application of superparamagnetic carbon nanotube contrast agent
  • Preparation and application of superparamagnetic carbon nanotube contrast agent
  • Preparation and application of superparamagnetic carbon nanotube contrast agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Example 1: Preparation of short carbon nanotubes.

[0048] MWNTs with micron-scale length were placed in mixed acid (H 2 SO 4 with HNO 3 The volume ratio is 3:1), sonicated for 16 hours. Rinse several times with double distilled water until neutral. Dry to obtain powdery short MWNTs with length distribution between 100-300nm.

Embodiment 2

[0049] Example 2: Preparation of superparamagnetic multi-walled carbon nanotubes by high temperature pyrolysis.

[0050] Put the quality of truncated MWNTs and ferrocene in a 30ml crucible and mix evenly, seal it in a stainless steel cylinder, put it in a muffle furnace and react at 350°C-425°C for 1-2h, then cool to room temperature. The collected black powder sample was repeatedly rinsed several times with pure ethanol solution to remove excess unreacted ferrocene. Finally, the powdery magnetic carbon nanotubes (MAGCNTs) were obtained by vacuum drying.

Embodiment 3

[0051] Example 3: Preparation of water-soluble MAGCNTs complex.

[0052] Preparation principle: layer by layer assembly.

[0053] A certain amount of MAGCNTs was weighed and added into a 1wt% PSS solution, and stirred at 65°C for 6-12h. The MAGCNTs-PSS complex was obtained by filtration and magnetic separation. Disperse the above complex into 20ml 1wt% PEI solution, centrifuge to remove excess PEI after shaking table reaction for 3h, obtain MAGCNTs-PSS-PEI complex (TEM figure 1 ). Polymer-wrapped multi-wall magnetic carbon nanotubes have good water solubility and can be well dispersed in different salt solutions ( figure 2 ).

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Abstract

The invention discloses the preparation and the application of a superparamagnetic carbon nanotube contrast agent, belonging to the technique magnetic resonance imaging. A traditional magnetic resonance imaging technique has small signal strength difference among benign tumor tissue, malignant tumor tissue and normal tissue and cannot achieve the purpose of accurate diagnosis. A multi-wall carbonnanotube and ferrocene are uniformly mixed to prepare a superparamagnetic multi-wall carbon nanotube by a high-temperature thermal decomposition method; then, after anionic polymers and cationic polymers are assembled and packed by layers, a water-soluble multi-wall superparamagnetic carbon nanotube, the surface of which has amino groups, is prepared and is connected with targeting agent folic acid by chemical bonds to further functional operation; and the water-soluble multi-wall superparamagnetic carbon nanotube is used as a targeting nuclear magnetic resonance contrast agent transfected tocervical cancer Hela cells cultured in vitro for enhancing MRI image effect. The invention has the advantages of simple preparation method of the contrast agent, small toxicity, high relaxation efficiency, good biological compatibility, suitability of various biological systems, good imaging effect and convenient diagnosis.

Description

technical field [0001] The invention belongs to magnetic resonance imaging technology, in particular to the preparation and application of a superparamagnetic carbon nanotube contrast agent. Background technique [0002] Magnetic resonance imaging (Magnetic Resonance Imaging, MRI) is the best imaging method in the existing medical imaging technology. MRI uses different tissues of the organism to generate different resonance signals under the influence of an external magnetic field for imaging. The strength of the signal depends on the water content in the tissue and the relaxation time of the protons in the water molecules. It has high tissue resolution, multiple imaging parameters, and the use of The outstanding advantages such as safety have important significance in tumor diagnosis and basic research. Although MRI has many of the above advantages, a large number of clinical cases have shown that MRI has little difference in signal intensity between benign and malignant t...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K49/06
Inventor 贾能勤殷敏田忠
Owner SHANGHAI NORMAL UNIVERSITY
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