Platinum complex compound with antitumor activity and synthesis method thereof

Abstract

The invention relates to a compound (1R,2R)-(1,2-cyclohexanediamine-N,N')-cis-(1,1-cyclopentane-carboxylic acid-O,O') platinum complex (I) with the antitumor activity and a synthesis method thereof. The antitumor activity of the compound is equivalent to that of oxaliplatin and that of carboplatin, and the toxic and side effect of the compound is lower than that of the oxaliplatin. A silver salt method or a potassium salt method is adopted to synthesize the compound, so the yield is good and the product has high purity.

Description

technical field The present invention relates to a kind of (1R,2R)-(1,2-cyclohexanediamine-N,N')-cis-(1,1-cyclopentanedicarboxylic acid-O,O) with anticancer activity ') combined with platinum (I) and its synthesis method, which belong to the technical field of anti-tumor platinum compounds. Background technique Cancer is a common and frequently-occurring disease that seriously threatens human health. Overcoming cancer has always been a research hotspot attracting worldwide attention. At present, humans have developed a variety of drugs for the prevention and treatment of cancer, among which platinum-based anticancer drugs have become indispensable drugs in cancer chemotherapy. In 1979, the first-generation platinum drug cisplatin was approved for marketing in the United States for the first time. The drug works well for testicular and ovarian cancer, and is also used to treat cancers of the bladder, neck, head, esophagus, and small cell lung cancer. In addition, it can b...

AI Technical Summary

Problems solved by technology

Platinum drugs are a class of compounds with broad-spectrum anti-tumor activity, but at the same time there are high toxic and side effects. In order to obtain compounds with lower toxic and side effects and better curative effects, a lot of research has been done on ammonia ligands and anion donors. research, and compounds with different structures enter different research stages

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