Method for production of dendritic cell

一种树突状细胞、细胞的技术，应用在生物化学设备和方法、动物细胞、脊椎动物细胞等方向，能够解决无法达到理想治疗效果、不能获取DC、DC前体细胞数量有限等问题
CN101755045AInactive Publication Date: 2010-06-23DNAVEC CORP
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
DNAVEC CORP
Publication Date
2010-06-23
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention provides a method for producing a dendritic cell (DC), which involves the step of culturing a DC precursor cell in the presence of two or more cytokines; a DC produced by the method; and use of the DC. The method can produce a large quantity of a DC precursor cell which is highly capable of being differentiated into a DC. The method can also produce a large quantity of a DC from a small quantity of a DC precursor cell. Therefore, it becomes possible to readily increase the number of DCs to be administered in the anti-tumor immunotherapy or the treatment of an infectious disease utilizing a DC, resulting in the enhancement of the efficacy of a DC vaccine.
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Description

technical field

[0001] The invention relates to a preparation method of dendritic cells, and provides the prepared dendritic cells and a utilization method thereof. Background technique

[0002] Dendritic cell (DC) is one of the antigen-presenting cells (APC) present in peripheral blood, skin, lymphoid organs and thymus, and is enriched in lymphoid tissue and non-lymphoid tissue (refer to Steinman, R.M.1991 , Ann. Rev. Immunol. 9:271; Banchereau, J.B. and R.M. Steinman, 1998, Nature 392:245). Dendritic cells have a strong ability to present antigens, which can express antigenic peptides to class I and class II dendritic cells, and activate CD4 and CD8 T cells, respectively, thereby inducing in vivo response to specific antigens (pathogenic microbial antigens) , tumor antigen, transplant antigen, etc.) immune response.

[0003] The powerful immune-inducing function of DC is very suitable for immunotherapy (DC treatment) of various tumors. Previous reports by the present in...

Claims

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