Composition of DC vaccine and NKG2A antagonist and application of composition in anti-breast cancer or liver cancer

An anti-breast cancer and antagonist technology, applied in the field of anti-breast cancer or liver cancer, the composition field of DC vaccine and NKG2A antagonist, can solve the problem of weakening dendritic cell antigen presentation function and immune response can not play a significant role Therapeutic effect, tumor killing and other issues, to achieve the effect of improving the continuous effect of immune response, enhancing the body's immune effect ability, safety and effectiveness
CN110575537APending Publication Date: 2019-12-17刘慧宁
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Patent Information

Authority / Receiving Office
CN · China
Current Assignee / Owner
刘慧宁
Publication Date
2019-12-17

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Abstract

The invention provides a composition of a DC vaccine and an NKG2A antagonist and application of the composition in anti-breast cancer or liver cancer. The DC vaccine in the composition is different from the early traditional tumor cell full-antigen-loaded DC vaccine, has specific targeting antigens, can more accurately treat tumors and reduce the killing side effects on normal cells; and secondly,the composition further contains a novel immune checkpoint inhibitor NKG2A antagonist which enables tumor cells with CD94-NKG2A / HLA-Ereceptor-ligand on the surface to be recognized and killed by NK cells and T cells, and an antigen presentation function of dendritic cells is enhanced, so that some cells which are not subjected to presentation and antigen by the DC vaccine are captured by an immune system again, the treatment effect on breast and liver cancer is enhanced, effect is faster than the conventional DC vaccine, the time of duration is longer, and the immunotherapy process is promoted.
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Description

technical field

[0001] The invention relates to the technical field of biological immunity, in particular to a composition of DC vaccine and NKG2A antagonist and its application in fighting breast cancer or liver cancer. Background technique

[0002] Breast cancer is a malignant tumor that occurs in the glandular epithelial tissue of the breast, 99% of which occur in women. The number of new breast cancer cases worldwide ranks first among female malignant tumors every year. In recent years, the incidence of breast cancer in China has also increased year by year. In 2017, it was as high as 43 / 100,000. Currently, breast cancer is clinically divided into 4 types: Luminal A type (ER+ / PR+, HER-2-), Luminal B type (ER+ / PR+, HER-2+), HER-2+ type (ER- / PR- / HER-2+) and triple-negative breast cancer (ER- / PR- / HER-2-). Among them, the current status of triple-negative breast cancer accounts for 15%-23.8% of all breast cancer pathological types. There are about 400,000 to 700,000 patie...

Claims

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