α-type Conus Polypeptide and Its Application

A technology of peptide derivatives and coding genes, which is applied in the field of α-type cone snail polypeptide, can solve the problems of poor treatment effect, tolerance of toxic and side effects, etc.
CN101792485BInactive Publication Date: 2012-02-08INST OF BIOENG ACAD OF MILITARY MEDICAL SCI OF THE CHINESE
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
INST OF BIOENG ACAD OF MILITARY MEDICAL SCI OF THE CHINESE
Publication Date
2012-02-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses an alpha-type conus polypeptide and its application. The present invention provides seven kinds of polypeptides: polypeptide I: the amino acid sequence is shown in sequence 7 of the sequence listing, and the last amino acid residue is amidated; polypeptide II: the amino acid sequence is shown in sequence 8 of the sequence listing, and the last amino acid residue is amidated Amino acid residues are amidated; Polypeptide III: the amino acid sequence is as shown in sequence 9 of the sequence listing, and the last amino acid residue is amidated; polypeptide IV: the amino acid sequence is as shown in sequence 10 of the sequence listing, and the last amino acid residue is Polypeptide V: the amino acid sequence is as shown in sequence 11 of the sequence listing, and the last amino acid residue is amidated; polypeptide VI: the amino acid sequence is as shown in sequence 12 of the sequence listing, and the last amino acid residue is amide Polypeptide VII: the amino acid sequence is shown in sequence 13 of the sequence listing. After activity measurement, it was found that 7 polypeptides of general formula I have analgesic effect, among which α cone polypeptide T-1, T-2, T-3, T-4 have significant analgesic activity, T5-T7 also have obvious analgesic activity Active and has application value in analgesia.
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Description

technical field

[0001] The invention relates to an alpha-type conus polypeptide and its application. Background technique

[0002] Cono snails belong to gastropod molluscs, and there are more than 500 species in the world, all over the world's warm sea areas. There are more than 100 species of cone snails in China, mainly distributed in my country's Xisha Islands, Hainan Island and Taiwan waters. Cono snail polypeptides are secreted by the venom glands of the cone snail venom tube and the inner wall of the poison sac. The venom of each cone snail contains 50-200 active peptides. Different species of cone snails contain different active peptides. Even the same species of taro Due to different sea areas of snails, there may also be differences in their toxin components. It is theoretically estimated that there are more than 50,000 polypeptides with different activities (McIntosh, J.M., Jones, R.M. (2001). Conevenom-from accidental stings to deliberate injection. Toxicon, 39 ,...

Claims

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