Inhibitors of acetyl-COA carboxylase for treatment of neuronal hypometabolism

A technology for hypometabolism and neurons, applied in chemical treatment to inactivate enzymes, nervous system diseases, medical preparations containing active ingredients, etc., can solve problems such as inability to slow down and treatment.
CN101795701AInactive Publication Date: 2010-08-04ACCERA INC
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
ACCERA INC
Publication Date
2010-08-04
Estimated Expiration
Not applicable · inactive patent

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Abstract

This invention relates to methods of using inhibitors of the enzyme acetyl-CoA carboxylase (ACC) for the treatment, prevention, inhibition or alleviation of diseases associated with neuronal hypometabolism and / or loss of cognitive function caused by reduced neuronal metabolism such as, for example, Age Associated Memory Impairment (AAMI), Mild Cognitive Impairment (MCI), Alzheimer's disease, Parkinson's disease, Friedreich's Ataxia (FRDA), GLUT1-deficient Epilepsy, Leprechaunism and Rabson-Mendenhall Syndrome, Coronary Arterial Bypass Graft (CABG) dementia, anesthesia induced memory loss, Huntington's disease and many others.
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Description

field of invention

[0001] The present invention relates to the field of therapeutic agents for the treatment of Alzheimer's disease, mild cognitive impairment and other diseases related to neuronal metabolic decline, including Parkinson's disease, Huntington's disease and epilepsy. Background of the invention

[0002] Many diseases are associated with neuronal hypoglucose metabolism and there is a need to treat these disorders. The compounds of the present invention are useful in the treatment of these disorders.

[0003] Alzheimer's disease (AD) is a progressive neurodegenerative disorder that mainly affects the elderly. In 1984, Blass and Zemcov (Blass and Zemcov 1984) proposed that AD results from a decreased metabolic rate in a subpopulation of cholinergic neurons. However, it has become clear that AD is not limited to the cholinergic system, but involves many types of transmission systems and several discrete brain regions. Decreased metabolic rate appears to correla...

Claims

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