Application of 3-carbethoxyphenyl-beta-D-acetylated glucoside in treating depression

Abstract

The invention relates to application of 3-carbethoxyphenyl-beta-D-acetylated glucoside in treating depression. The 3-carbethoxyphenyl-beta-D-acetylated glucoside comprises a pharmaceutically acceptable salt, ester or a solvate thereof, and the application relates to the application of the salt, the ester and the solvate in preparing medicaments for treating the depression, wherein a glycosyl part is arbitrary pyranose or furanose, the hydroxy of which is totally acetylated; a representative compound is 3-carbethoxyphenyl-beta-D-acetylated glucoside; and the structural formula is disclosed in the specification. The compound is used for treating the depression, on two depression behavior models, through 45mg / Kg of single intragastric administration to a mouse of a KM species, the representative compound 3-carbethoxyphenyl-beta-D-acetylated glucoside shows definite depression resistant effect, and the depression resistant effect of the compound is higher than that of Hilieidum with equivalent quantity. A test on the spontaneous activity of the mouse also indicates that an effective dose point does not show the effect of interfering in the spontaneous activity of the tested animal.

Description

technical field The present invention relates to the field of medicinal chemistry, specifically, the present invention relates to small molecule phenolic glycoside compounds 3-ethoxycarbonylphenyl-β-D-acylated glycosides and pharmaceutically acceptable salts, esters and solvates thereof for use in The preparation is used for treating depression. Background technique Depression is the main type of mood disorders. It is a syndrome characterized by significant and persistent depression. Self-harm urges or suicidal thoughts. Selective serotonin reuptake inhibitors (SSRIs), such as fluoxetine, paroxetine, sertraline, and citalopram, are currently the first-choice drugs for the clinical treatment of depression. (citalopram), etc., are characterized by specifically blocking the reuptake of 5-HT, but have a low affinity to other neurotransmitter receptors in the brain, and have less toxic and side effects compared with general classic antidepressants; but its onset The effective...

AI Technical Summary

Problems solved by technology

But generally speaking, the current clinically applied drugs still fail to achieve satisfactory results in terms of drug efficacy, side effect control, and addiction control, and further research and development and improvement are needed.

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