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Chinese medicinal composition for preventing renal cell apoptosis and anemia caused by cis-platinum (DDP) and preparation method thereof

A composition and technology of traditional Chinese medicine, applied in the field of traditional Chinese medicine composition and its preparation, can solve problems such as lack of pertinence, and achieve the effects of easy popularization and application, convenient taking, and reduced economic burden

Inactive Publication Date: 2010-09-29
BEIJING UNION UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these traditional Chinese medicine prescriptions have alleviated the toxic and side effects of DDP in some aspects, they are not very specific for some obvious toxic and side effects such as DDP-induced anemia and renal cell apoptosis

Method used

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  • Chinese medicinal composition for preventing renal cell apoptosis and anemia caused by cis-platinum (DDP) and preparation method thereof
  • Chinese medicinal composition for preventing renal cell apoptosis and anemia caused by cis-platinum (DDP) and preparation method thereof
  • Chinese medicinal composition for preventing renal cell apoptosis and anemia caused by cis-platinum (DDP) and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] Embodiment 1, preparation prevents the Chinese medicine composition of anemia caused by cisplatin

[0053] Prepare the traditional Chinese medicine composition for preventing anemia caused by cisplatin with the method of the present invention, the specific method comprises the following steps:

[0054] 1) Weigh raw materials: 50g ginseng, 200g astragalus, 200g rehmannia, 100g Atractylodes macrocephala, 100g angelica, 150g medlar, 100g fleece-flower root, 100g privet fruit, 100g poria, 100g bupleurum, 100g turmeric, 150g barley.

[0055] 2) Washing and drying the crude drug.

[0056] 3) Soak the raw medicine in cold water for 5 hours (4-6 hours are all acceptable), then decoct it under normal pressure for 2.5 hours (2-3 hours are all acceptable), and the resulting decoction is allowed to stand for 20 hours (12-28 hours either), the supernatant was concentrated into an extract, granulated, dried, packed into capsules or made into water pills, and a traditional Chinese me...

Embodiment 2

[0057] Embodiment 2, preparation prevents the Chinese medicine composition of anemia caused by cisplatin

[0058] Prepare the traditional Chinese medicine composition for preventing anemia caused by cisplatin with the method of the present invention, the specific method comprises the following steps:

[0059] 1) Weigh raw materials: 100g ginseng, 300g astragalus, 200g rehmannia, 150g Atractylodes macrocephala, 100g angelica, 100g medlar, 100g fleece-flower root, 100g privet fruit, 100g poria, 100g bupleurum, 100g turmeric, 150g barley.

[0060] 2) Washing and drying the crude drug.

[0061] 3) Soak the raw medicine in cold water for 4 hours, decoct it under normal pressure for 3 hours, let the resulting decoction stand for 28 hours, take the supernatant and concentrate it into an extract, granulate, dry, and make water pills to prevent A traditional Chinese medicine composition for anemia caused by cisplatin.

Embodiment 3

[0062] Embodiment 3, preparation prevents the Chinese medicine composition of anemia caused by cisplatin

[0063] Prepare the traditional Chinese medicine composition for preventing anemia caused by cisplatin with the method of the present invention, the specific method comprises the following steps:

[0064] 1) Weigh raw materials: 50g ginseng, 200g astragalus, 200g rehmannia, 100g Atractylodes macrocephala, 300g angelica, 100g medlar, 200g fleece-flower root, 100g privet fruit, 100g poria, 60g bupleurum, 150g turmeric, 150g barley.

[0065] 2) Washing and drying the crude drug.

[0066] 3) Soak the raw medicine in cold water for 6 hours, decoct it under normal pressure for 2 hours, let the resulting decoction stand for 12 hours, take the supernatant and concentrate it into an extract, granulate, dry, and pack into capsules to obtain prophylaxis A traditional Chinese medicine composition for anemia caused by cisplatin.

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Abstract

The invention discloses a Chinese medicinal composition for preventing renal cell apoptosis and anemia caused by cis-platinum (DDP) and a preparation method thereof. The Chinese medicinal composition comprises the following raw material medicaments in part by weight: 5 to 10 parts of ginseng, 20 to 30 parts of astragalus, 20 to 30 parts of root of rehmannia, 10 to 15 parts of largehead atractylodes rhizome, 10 to 30 parts of Chinese angelica, 10 to 15 parts of medlar, 10 to 30 parts of tuber fleeceflower root, 10 to 15 parts of glossy privet fruit, 10 to 15 parts of Indian buead, 6 to 10 parts of bupleurum, 10 to 15 parts of turmeric root-tuber and 15 to 30 parts of pearl barley. The preparation method comprises the following steps of: 1) washing the raw material medicaments and drying the washed raw material medicaments; and 2) soaking the raw material medicaments in cold water for 4 to 6 hours, decocting the soaked medicaments under normal pressure for 2 to 3 hours, standing obtained decoction for 12 to 28 hours, condensing supernate into extract, granulating the extract and drying the granules to obtain the Chinese medicinal composition. The Chinese medicinal composition of the invention is an effective medicament for relieving renal toxicity and blood toxicity of the DDP, can enhance the anti-tumor activity of the DDP and can be used in the treatment of various malignant tumors together with the DDP.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition and a preparation method thereof, in particular to a traditional Chinese medicine composition for preventing renal cell apoptosis and anemia caused by cisplatin and a preparation method thereof. Background technique [0002] Cisplatin (DDP) is a widely used anticancer drug. Clinical studies have shown that: DDP has strong anti-cancer effects and has no cross-resistance with other anti-cancer drugs. It has achieved remarkable curative effects in the treatment of various malignant tumors. It is currently a promising anti-cancer drug. But DDP has obvious toxicity: [0003] One of the toxicity: clinical application of DDP to treat tumor patients often causes anemia and decreased Hb level, and Hb plays a role that cannot be ignored in tumor treatment. Studies have found that the effects of Hb nitric oxide (NO) synthase inhibitors and NO scavengers can reduce the dilation effect of NO on b...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61P35/00A61P13/12A61P7/06
Inventor 高丽萍
Owner BEIJING UNION UNIVERSITY