Novel salvianolic acid compound L and preparation method and application thereof
A technology of salvianolic acid and compound, applied in the field of new salvianolic acid compounds, can solve problems such as compounds and pharmacological effects that have not been reported and the like
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Embodiment 1
[0085] The preparation of embodiment 1 salvianolic acid L
[0086] Take Danshen decoction pieces, put them in an extractor, add 4 times the volume of medicinal materials in water (containing 0.45% sodium bicarbonate), decoct for 2 hours, and filter; continue decocting medicinal residues with 3 times the volume of water for 1 hour, filter, and combine The filtrate is concentrated to an extract with a relative density of 1.2 (80°C); 95% ethanol is added to the extract to carry out alcohol precipitation to 70% (25°C), and it is allowed to stand for more than 12 hours. The ethanol is recovered under reduced pressure and concentrated to a relative density of 1.37 (60°C) extract.
[0087] The obtained extract was dissolved in water, passed through AB-8 macroporous adsorption resin, washed with water 12 times the volume of the column bed, and the water eluent was adjusted to pH 3.0 with hydrochloric acid. Pass the above acidic water eluent through AB-8 macroporous adsorption resin...
Embodiment 2
[0093] The preparation of embodiment 2 salvianolic acid L
[0094] Take Danshen and Panax notoginseng decoction pieces, put them in the extractor, add 6 times the volume of medicinal materials in water (containing 0.45% sodium bicarbonate), decoct for 3 hours, and filter; continue to decoct the medicinal residues with 5 times the volume of water for 2 hours, filter After that, the combined filtrates were concentrated to extracts with a relative density of 1.25 (80°C); 95% ethanol was added to the extracts to carry out alcohol precipitation to 68% (25°C), and they were left to stand for more than 12 hours, and the ethanol was recovered under reduced pressure and concentrated to a relative density. An extract with a density of 1.32 (60°C).
[0095] The obtained extract was dissolved in water, passed through AB-8 macroporous adsorption resin, washed with water 12 times the volume of the column bed, and the water eluent was adjusted to pH 2.5 with hydrochloric acid. Pass the ab...
Embodiment 3
[0101] The preparation of embodiment 3 salvianolic acid L
[0102] Take Danshen decoction pieces, put them in an extractor, add 85% ethanol with 6 times the volume of medicinal materials, decoct twice for 2 hours each time, filter, and discard the ethanol extract.
[0103] Add 4 times the amount of water (containing 0.45% sodium bicarbonate) to the medicinal residues, decoct for 2 hours, and filter; continue to decoct the medicinal residues with 3 times the volume of water for 1 hour, filter, combine the filtrates, and concentrate until the relative density is 1.2 (80°C) extract; add 95% ethanol to the extract for alcohol precipitation to 70% (25°C), let it stand for more than 12 hours, recover ethanol under reduced pressure, and concentrate to extract with a relative density of 1.37 (60°C) .
[0104] The obtained extract was dissolved in water, passed through AB-8 macroporous adsorption resin, washed with water 12 times the volume of the column bed, and the water eluent wa...
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Abstract
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