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Chinese-medicinal composition for treating coronary heart disease and its preparation method

A composition and technology for coronary heart disease, applied in the preparation of traditional Chinese medicine compositions, in the field of traditional Chinese medicine compositions for the treatment of coronary heart disease, can solve the problems of inconclusive, difficult to control, and uncertain side effects, and achieve the effect of anti-acute myocardial ischemia Effects of myocardial angiogenesis, promotion of ischemic myocardial angiogenesis, and high yield of target components

Inactive Publication Date: 2009-09-30
NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the promotion of angiogenesis is a multi-target and multi-link process, it is temporarily uncertain which growth factor and treatment plan to use
[0005] ②Safety: Whether systemic administration will cause abnormal blood vessel growth in other parts, or even promote the occurrence of potential tumors, especially in the practical application of gene therapy, it is currently difficult to control, and the side effects cannot be determined for the time being without the support of long-term follow-up data
[0006] ③ Feasibility: If the curative effect cannot be sustained and repeated administration is required, whether it is to use a large amount of exogenous recombinant protein or perform transgene expression, not only the cost is quite expensive, but also the operation is complicated and inconvenient, which is difficult for patients to accept.
[0007] Due to the above problems, many techniques of therapeutic angiogenesis cannot be applied clinically for the time being

Method used

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  • Chinese-medicinal composition for treating coronary heart disease and its preparation method
  • Chinese-medicinal composition for treating coronary heart disease and its preparation method
  • Chinese-medicinal composition for treating coronary heart disease and its preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Weigh raw materials: 24 grams of rhodiola, 432 grams of astragalus, and 24 grams of angelica. Add 10 times the amount of water to the raw materials, heat and reflux for extraction for 2 hours, and filter; then add 10 times the amount of water and heat and reflux Extract for 1h, filter; discard the drug residue, and combine the two extracts. Concentrate and dry to obtain a dry extract; add appropriate amount of auxiliary materials to obtain granules.

Embodiment 2

[0068] Weigh raw materials: 40 grams of rhodiola, 120 grams of astragalus, 40 grams of angelica, process the raw materials into 20 mesh medicinal powder, add 5 times the amount of 70% ethanol, irradiate with 170W microwave power for 5 minutes, filter, take the filtrate, Concentrate and dry to obtain a dry extract, and add appropriate amount of auxiliary materials to obtain granules.

Embodiment 3

[0070] Weigh raw materials: 60 grams of rhodiola, 80 grams of astragalus, and 60 grams of angelica, process the raw materials into 100-mesh medicinal powder, add 6 times the amount of 5% ethanol to soak for 60 minutes, irradiate with 85W microwave power for 60 minutes, filter, and take The filtrate was concentrated and dried to obtain a dry extract, and an appropriate amount of auxiliary materials was added to obtain granules.

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Abstract

The invention discloses a traditional Chinese medicine composition for treating coronary heart disease, which is mainly prepared from rhodiola, astragalus and angelica in a certain weight ratio, and can be prepared into any common oral preparation. The traditional Chinese medicine composition of the invention has both anti-acute myocardial ischemia effect and the effect of promoting angiogenesis in ischemic myocardium, and can effectively treat coronary heart disease. The invention also discloses a preparation method of the traditional Chinese medicine composition for treating coronary heart disease, which adopts a microwave-assisted extraction process. The preparation method improves the yield of target components while ensuring the efficacy of the product.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating coronary heart disease; in addition, the invention also relates to a preparation method of the traditional Chinese medicine composition for treating coronary heart disease. Background technique [0002] Coronary heart disease (CHD) is caused by coronary artery stenosis or occlusion leading to myocardial ischemia, hypoxia or necrosis, resulting in various clinical symptoms and comorbidities. At present, the three internationally recognized treatment approaches include drug therapy, interventional therapy and surgical treatment. Since most drugs have limited effect on the treatment of severe myocardial ischemia, and interventional therapy and surgical treatment cannot prevent restenosis in other parts of the coronary artery, these three treatments can only temporarily relieve the symptoms of coronary heart disease,...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/71A61K36/481A61K36/232A61K36/48A61K9/08A61K9/00A61P9/10
Inventor 阮克锋范维虎王娟李勇沈平孃蒋霞林志宏叶子
Owner NAT ENG RES CENT FOR TRADITIONAL CHINESE MEDICINE