Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for preparing sodium glycerophosphate

A technology of sodium glycerophosphate and glycerin, which is applied in the field of chemical medicine, can solve the problems of low content of β-sodium glycerophosphate and lack of pharmaceutical activity of α-sodium glycerophosphate, and achieve proper ratio of raw materials, reduce production costs, and process parameters reasonable effect

Active Publication Date: 2012-10-10
紫光古汉集团衡阳制药有限公司
View PDF0 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among them, β-sodium glycerophosphate is the medicinal part, while α-sodium glycerophosphate does not have medicinal activity. Currently, the content of β-sodium glycerophosphate produced by the existing synthesis process is relatively low

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for preparing sodium glycerophosphate
  • Method for preparing sodium glycerophosphate
  • Method for preparing sodium glycerophosphate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0048] The preparation method of sodium glycerophosphate:

[0049] (1) Salt formation and esterification

[0050] Quantitative phosphoric acid and glycerol are put into the esterification reaction cylinder, then add sodium carbonate, the three are sodium carbonate 53g, phosphoric acid 98g, glycerol 184g by weight;

[0051] Introduce steam; in the reaction cylinder, phosphoric acid and sodium carbonate undergo a salt reaction to generate sodium dihydrogen phosphate, and then sodium dihydrogen phosphate and glycerin undergo an esterification reaction to generate diglyceride sodium glycerophosphate; the reaction process controls the pH value to 4.6 and maintains the vapor pressure 0.4-0.5MPa, reaction temperature 135°C; after the reaction, add an appropriate amount of purified water to dilute it;

[0052] (2) Hydrolysis

[0053] After esterification, add 45ml of 30% sodium hydroxide solution; sodium glycerophosphate and sodium hydroxide undergo hydrolysis reaction to generate s...

Embodiment 2

[0095] The preparation method of sodium glycerophosphate:

[0096] (1) Salt formation and esterification

[0097] Quantitative phosphoric acid and glycerol are put into the esterification reaction cylinder, then add sodium carbonate, the three are sodium carbonate 53g, phosphoric acid 98g, glycerol 184g by weight;

[0098] Steam is introduced; phosphoric acid and sodium carbonate undergo a salt reaction in the reaction cylinder to generate sodium dihydrogen phosphate, and then sodium dihydrogen phosphate and glycerin undergo an esterification reaction to generate diglyceride sodium glycerophosphate; the reaction process controls the pH value to 3.0-5.5, and maintains Vapor pressure 0.4-0.5MPa, reaction temperature 130°C; after the reaction, add an appropriate amount of purified water to dilute it;

[0099] (2) Hydrolysis

[0100] After esterification, add 40ml of 30% sodium hydroxide solution; sodium glycerophosphate and sodium hydroxide undergo hydrolysis reaction to genera...

Embodiment 3

[0113] The preparation method of sodium glycerophosphate:

[0114] (1) Salt formation and esterification

[0115] Quantitative phosphoric acid and glycerin are put into the esterification reaction cylinder, then add sodium carbonate, the three are sodium carbonate 55g, phosphoric acid 100g, glycerol 165g by weight;

[0116] Introduce steam; in the reaction tank, phosphoric acid and sodium carbonate undergo a salt reaction to generate sodium dihydrogen phosphate, and then sodium dihydrogen phosphate and glycerin undergo an esterification reaction to generate diglyceride sodium glycerophosphate; the reaction process controls the pH value to 4.5 and maintains the vapor pressure 0.5MPa, reaction temperature 125°C; after the reaction, add an appropriate amount of purified water to dilute it;

[0117] (2) Hydrolysis

[0118] After esterification, add 37ml of 30% sodium hydroxide solution; sodium glycerophosphate and sodium hydroxide undergo a hydrolysis reaction to generate sodium...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a method for preparing sodium glycerophosphate. The method comprises the steps of: taking 40-65g of sodium carbonate, 80-110g of phosphoric acid and 160-200g of glycerin in parts by weight; putting the phosphoric acid and the glycerin into an esterification reactor, adding the sodium carbonate, and introducing vapor; controlling the pH value to be 3.0-5.5 in the reaction process, maintaining the pressure of the vapor to be 0.4-0.5MPa and the reaction temperature to be 120-145 DEG C; adding a proper amount of purified water after reaction for diluting; after esterification, adding 30% of sodium hydroxide solution; then, carrying out reflux for 8-12 hours after boiling; adding 1-6ml of NaOH, and controlling the pH value to be 8.0-11.0; adding MgO according to the content of intermediate free phosphate after hydrolyzation so as to eliminate free phosphate generated in reaction; concentrating raw sodium glycerophosphate, and separating free glycerin; and decoloringthe qualified separated raw sodium glycerophosphate to obtain the sodium glycerophosphate. The sodium glycerophosphate prepared by the method has a high content of beta-sodium glycerophosphate, and the yield is high.

Description

technical field [0001] The invention relates to a preparation method of sodium glycerophosphate, which belongs to the field of chemical medicine. Background technique [0002] As a nutraceutical, sodium glycerophosphate is a mixture of α-sodium glycerophosphate and β-sodium glycerophosphate. Among them, sodium β-glycerophosphate is the medicinal part, while sodium α-glycerophosphate does not have medicinal activity. Currently, the content of sodium β-glycerophosphate produced by the existing synthesis process is relatively low. [0003] Contents of the invention [0004] The purpose of the present invention is to provide a preparation method of sodium glycerophosphate, in which the content of β-sodium glycerophosphate is high. [0005] The object of the invention is achieved through the following technical solutions: [0006] A preparation method of sodium glycerophosphate, the method is: [0007] Step 1: select raw materials to be: sodium carbonate, phosphoric acid,...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): C07F9/09
Inventor 申辛
Owner 紫光古汉集团衡阳制药有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com