Gadolinium-containing macromolecular contrast agent for specific imaging of lymphatic system and preparation method thereof

Abstract

The invention relates to a gadolinium-containing macromolecular contrast agent HA-DTPA-Gd for specific imaging of a lymphatic system and a preparation method thereof. The molecular structure of the contrast agent is shown in the specifications. A macromolecular magnetic resonance imaging (MRI) contrast agent prepared by the method has a high molecular weight and is mainly absorbed by capillary lymph ducts but cannot enter blood capillaries after interstitial administration; and simultaneously, hyaluronic acid molecules are taken as the main chain of the contrast agent so that the contrast agent is easily absorbed by a lymphatic endothelial hyaluronic acid receptor LYVE-1 in the capillary lymph ducts to enter the lymphatic system. Therefore, the contrast agent has the advantages of realizing active targeting of lymph, avoiding the disturbance of the capillary lymph ducts in the MRI of the lymphatic system and improving the sensitivity and specificity of lymph qualitative diagnosis.

Description

technical field The invention relates to a preparation method of a novel gadolinium-containing magnetic resonance contrast agent, in particular to a gadolinium-containing macromolecular contrast agent HA-DTPA-Gd for lymphatic system specific imaging and a preparation method thereof. Background technique: With the development of micro-lymphatic surgery technology, higher requirements are put forward for the classification and localization diagnosis of lymphatic reflux disorders; at the same time, it is more accurate and sensitive to display the structure of lymphatic vessels and lymph nodes, and judge their functional status Accurate staging of tumor patients is the basis for formulating treatment plans, judging prognosis, and effectively preventing postoperative lymphedema. It is also the key to the diagnosis and treatment of lymphatic system diseases. Lymphography has always been considered the "gold standard" for imaging lymphatic structure and judging the pathological nat...

AI Technical Summary

Problems solved by technology

According to modern medical research on lymphatic vessels, the wall of capillary lymphatic vessels is only composed of a layer of flat epithelial cells, with loose connections, lack of a complete basement membrane, high permeability, and the absorption of large molecular weight substances mainly by it

Images