Beta-lactam antibiotic solution and preparation method thereof
A technology for lactams and antibiotics, applied in the field of β-lactam antibiotics solution and its preparation, can solve the problems of high blood drug concentration, slow drug effect, inhomogeneity of drug components and liquid components, etc., and achieve simple preparation process , high bioavailability
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Embodiment 1
[0032] (1) Preparation ingredients:
[0033] β-lactam antibiotics: Penicillin 5g
[0034] Solvent: 2-pyrrolidone 10mL
[0035] Propylene glycol 90mL
[0036] (2) Preparation method
[0037] Take 80% of the prescription amount of mixed solvent, put it in a clean, dry and heatable container, heat it to 40°C, slowly add penicillin, stir until it is completely dissolved; put it at room temperature, stir while adding, adjust the volume of the mixed solvent, filter, Potting, that is.
Embodiment 2
[0039] (1) Preparation ingredients:
[0040] β-lactam antibiotics: Ampicillin 5g
[0041] Solvent: 2-pyrrolidone 20mL
[0042] Propylene glycol 80mL
[0043] (2) Preparation method
[0044] Take 80% of the prescription amount of mixed solvent, place it in a clean, dry and heatable container, heat it to 50°C, slowly add penicillin, stir until it is completely dissolved; put it at room temperature, stir while adding, adjust the volume of the mixed solvent, filter, Potting, that is.
Embodiment 3
[0046] (1) Preparation ingredients:
[0047] β-lactam antibiotics: Hydroxybenicillin 5g
[0048] Solvent: 2-pyrrolidone 30mL
[0049] Propylene glycol 70mL
[0050] Preservative: Sodium Benzoate 0.1g
[0051] (2) Preparation method
[0052] Take 80% of the prescription amount of mixed solvent, place it in a clean, dry and heatable container, heat it to 60°C, slowly add oxybenicillin, stir until it is completely dissolved; put it at room temperature, and slowly add the preservative benzene Sodium formate, stirring while adding, mixed solvent to constant volume, filtering, potting, that is.
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