44 results about "Cell swelling" patented technology

A composition comprising a novel Ca2+-activated, [ATP]i-sensitive nonspecific cation (NCCa-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nucleotides, and is activated by submicromolar [Ca]i. The NCCa-ATP channel is activated under conditions of ATP depletion, which causes severe cell depolarization, followed by cell swelling. The NCCa-ATP channel is regulated by a sulfonylurea receptor and is inhibited by sulfonylurea compounds glibenclamide and tolbutamide. Methods employing compositions comprising the NCCa-ATP channel to screen for compounds that block the channel and the use of such antagonists as therapeutics in preventing brain swelling and damage are described. In addition, methods employing compositions comprising the Kir2.3 channel to screen for compounds that open the channel and the use of such antagonists as therapeutics in preventing brain swelling and damage are described.

A non-aqueous electrolyte secondary cell that has high capacity and excellent cycle characteristic while preventing cell swelling is provided. The positive electrode of the cell has, as the positive electrode active material, lithium nickel composite oxide represented by LixNi1-yMyOz where 0.9<x≦1.1, 0≦y≦0.7, 1.9≦z≦2.1, and M contains at least one selected from Al, Co, and Mn. The amount of lithium carbonate on the surface of the lithium nickel composite oxide is 0.20 mass % or less relative to the lithium nickel composite oxide. On the surface of the positive electrode, a porous layer having inorganic oxide and lithium carbonate is provided.

Electrolytes for use in commercially viable, rechargeable lithium metal batteries are described. The electrolytes contain one or more lithium salts, one or more organic solvents, and one or more additives. The electrolytes allow for reversible deposition and dissolution of lithium metal. Specific additives or additive combinations dramatically improved cycle life, decrease cell swelling, and / or lower cell impedance.

A nonaqueous electrolyte secondary battery comprising a negative electrode constituted of a carbonaceous material permitting reversible insertion and desorption of lithium, a positive electrode permitting reversible insertion and desorption of lithium, a separator separating these positive electrode and negative electrode from each other and a nonaqueous electrolyte composed of an organic solvent and, dissolved therein, a solute of lithium salt, wherein the nonaqueous electrolyte contains vinylene carbonate and di(2-propynyl) oxalate, these vinylene carbonate and di(2-propynyl) oxalate added in an amount of 0.1 to 3.0% by mass and 0.1 to 2.0% by mass, respectively, based on the mass of the nonaqueous electrolyte. Thus, there can be provided a nonaqueous electrolyte secondary battery wherein a stable SEI surface coating is formed to thereby exhibit a large initial capacity and excel in cycle characteristics at high temperature and wherein any cell swelling is slight.

An assembled battery device comprising a plurality of single cells which are placed with a predetermined space between each of them and an element for detecting swelling is set in the predetermined space between the single cells and operates in accordance with the transformation of the single cells by swelling. Therefore, when a single cell swells and transforms, resulting from being overcharged, the element for detecting swelling is activated in accordance with such transformation and detects the state of overcharging.

A method and apparatus for detecting and responding to cell swell in one or more cells of a battery includes receiving one or more indications of cell swell from switching circuitry associated with a cell, determining if the battery is fit for purpose based on the one or more indications, and performing an action responsive to the one or more indications and whether the battery is fit for purpose.

Provided are a battery pack and a control method using the same, the battery pack having improved safety so as to prevent fire or prevent fire from spreading even if ignited, thereby reducing the risks which can occur during ignition. The battery pack, according to the present invention, comprises: an electrode assembly comprising an anode, a cathode, and a separator; and a single cell or a plurality of cells having a pouch-shaped battery case for accommodating the electrode assembly, wherein the cell is accommodated and stacked by the module case, the module case comprises a fire suppression agent or a fire extinguishing agent at the inner or outer part thereof such that the fire suppression agent or the fire extinguishing agent is automatically discharged from the module case when cell swelling occurs.

The invention discloses a preparation process of wall broken spirulina protein powder. The preparation process of the wall broken spirulina protein powder comprises the following steps of: pulverizing wall broken spirulina with a pulverizer, soaking wall broken spirulina powder in water for 5-10 hours, taking out the soaked wall broken spirulina powder, and pulverizing under ultrasonic waves; soaking spirulina cells with distilled water or a low-salt solution directly so that the spirulina cells swell and break to release wall broken spirulina protein, wherein the wall broken spirulina protein is soaked in distilled water for 10 days, or the wall broken spirulina protein is soaked in the low-salt solution for 3-4 days; weighing 5.99g of wall broken spirulina protein powder, and soaking in distilled water for 12 days for swelling fully; filtering with a piece of filtering cloth of 74mu m, centrifuging a filtrate at the temperature of 4 DEG C and 5500g for 20 minutes, removing spirulina residues, and taking a purplish red supernatant which is the crude extract of wall broken spirulina protein. The preparation process of the wall broken spirulina protein powder is simple, and the prepared wall broken spirulina protein powder has a high nutritional value.

Electrolytes for use in commercially viable, rechargeable lithium metal batteries are described. The electrolytes contain one or more lithium salts, one or more organic solvents, and one or more additives. The electrolytes allow for reversible deposition and dissolution of lithium metal. Specific additives or additive combinations dramatically improved cycle life, decrease cell swelling, and / or lower cell impedance.

Methods of decreasing the extent of occlusion in the lumen of a mammalian blood vessel due to an ischemic or other hypoxic event are provided. In one form, a method includes administering to a patient in need thereof a pharmaceutically effective amount of an inhibitor of δ protein kinase C, either alone or in combination with a second therapeutic agent, and wherein the blood vessel is a blood vessel of the microvasculature. Additionally, methods of decreasing endothelial cell swelling in a mammalian blood vessel due to an ischemic or other hypoxic event are also provided. In one form, a method includes administering to a patient in need thereof a pharmaceutically effective amount of an inhibitor of δ protein kinase C, either alone or in combination with a second therapeutic agent.

An assembled battery device comprising a plurality of single cells which are placed with a predetermined space between each of them and an element for detecting swelling is set in the predetermined space between the single cells and operates in accordance with the transformation of the single cells by swelling. Therefore, when a single cell swells and transforms, resulting from being overcharged, the element for detecting swelling is activated in accordance with such transformation and detects the state of overcharging.

A method and apparatus for detecting and responding to cell swell in one or more cells of a battery includes receiving one or more indications of cell swell from switching circuitry associated with a cell, determining if the battery is fit for purpose based on the one or more indications, and performing an action responsive to the one or more indications and whether the battery is fit for purpose.

A safety device for preventing overcharging of a battery includes: a battery stack including a plurality of cells; a safety circuit connected to two or more cells and provided with an electrical conduction control unit that controls electrical conduction; and a closed circuit disposed between the cells connected to the safety circuit and provided with a switching unit which is switched on or off upon cell swelling, such that when cell swelling occurs, the switching unit is switched on by a pressing force, disabling the electrical conduction control unit of the safety circuit so electrical conduction between the cells is established via the switching unit, and when cell swelling occurs again, the switching unit is switched off, cutting off the electrical conduction between the cells.

A safety device for preventing overcharging of a battery includes: a battery stack including a plurality of cells; a safety circuit connected to two or more cells and provided with an electrical conduction control unit that controls electrical conduction; and a closed circuit disposed between the cells connected to the safety circuit and provided with a switching unit which is switched on or off upon cell swelling, such that when cell swelling occurs, the switching unit is switched on by a pressing force, disabling the electrical conduction control unit of the safety circuit so electrical conduction between the cells is established via the switching unit, and when cell swelling occurs again, the switching unit is switched off, cutting off the electrical conduction between the cells.

The invention discloses a drug for preventing and treating the alcoholic liver disease. Active ingredients of the drug comprise lactobacillus rhamnosus liquid supernatant and vitamin E, and preferablytanshinone IIA sodium sulfonate is added. Based on the modern pathological study, the drug is combined with the theory of traditional Chinese medicine; according to the curative effect, the drug hasthe effects of restoring intestinal barrier damages caused by alcohol, improving oxidization resistance of livers, improving cellular swelling and fatty degeneration of the livers, relieving fibrous septum, and the like, and has obvious prevention and treatment effect on acute alcoholic liver injury and alcohol hepatic fibrosis.

This invention relates generally to cryopreservation and a method for preventing injury caused by cooling and warming of tissue and for reducing the toxicity of vitrification solutions. The present method achieves reduction or elimination of injury by increasing the tonicity of the medium to greater than isotonic prior to cooling. The method was developed by attempting to simulate without freezing, the events that take place during freezing living cells and / or tissue. A further benefit of the method is that, since the cryopreservation medium is hypertonic, it can be diluted to a more extreme degree in one step once the system is rewarmed, without engendering the degree of cell swelling that would attend the same dilution factor when diluting an isotonic cryopreservation medium.

The invention discloses a detection device and a device method for the packaging effect of soft pack lithium batteries. The detection device comprises a vacuum chamber, a vacuum pump and a detection unit. The detection unit comprises a support frame disposed in the vacuum chamber, the support frame is provided with a locking device, and a dial gauge fixed to the support frame through the locking device is used for observing the swelling height of aluminum plastic films in the vacuum chamber and height variations with time. A pressure plate is connected to the bottom end of the dial gauge, drives a pointer of the dial gauge to rotate along with the expansion and contraction of the aluminum plastic films, and is used for observing value changes and determining the packaging effect. The detection method has the advantages that the cell packaging effect is simulated before batched packaging of cells, and interferences from other procedures are eliminated; the packaged aluminum plastic films are tested in the vacuum chamber, the interiors of the aluminum plastic films are highly stressed under the negative pressure of above -85KPa, whether the packaging is good or not can be tested in ashort time, and whether the aluminum plastic films can be expanded or not when the cells swell in later period can be simulated.

A composition comprising a novel Ca2+-activated, [ATP]i-sensitive nonspecific cation (NCCa-ATP) channel is described. The channel is found in mammalian neural cells and exhibits a different sensitivity to block by various adenine nucleotides, and is activated by submicromolar [Ca]i. The NCCa-ATP channel is activated under conditions of ATP depletion, which causes severe cell depolarization, followed by cell swelling. The NCCa-ATP channel is regulated by a sulfonylurea receptor and is inhibited by sulfonylurea compounds glibenclamide and tolbutamide. Methods employing compositions comprising the NCCa-ATP channel to screen for compounds that block the channel and the use of such antagonists as therapeutics in preventing brain swelling and damage are described. In addition, methods employing compositions comprising the Kir2.3 channel to screen for compounds that open the channel and the use of such antagonists as therapeutics in preventing brain swelling and damage are described.

A method is disclosed for removal of cryoprotectants from preserved suspension of biological cells and tissues. Sorbent materials are used, alone or in combination, to bind the cryoprotectant component of preserved cell suspensions with minimal osmotic stress on the preserved cells. The present method is used to effectively remove the cryoprotectants from cryopreserved cells and tissues prior to their use in transfusion, transplantation, insemination or other applications, with minimal osmotic damage due to cell swelling. Specific devices and methods are described.

The invention relates to a terahertz wave technology-based unmarked aquaporin function assessment method. According to the method, cells are inoculated on the surface of a constructed terahertz metamaterial chip, culture is carried out to ensure that the cells grow in an adherent state and are fused into a single-cell layer, and a terahertz time-domain spectrograph is adopted to measure the harmonic peak condition of a cell layer in isotonic buffer solution; and hypotonic buffer solution is changed, and a large number of water molecules enter the cells through aquaporins to ensure that the volumes of the initial cells are increased so as to form swelled cells. According to the method, the terahertz time-domain spectrograph is adopted to obtain the harmonic peak change condition of the adherent cell layer during osmotic pressure change, so that the cell swelling degree is effectively reflected, namely, the osmosis condition of the water molecules passing through the cell layer; and thereciprocal of a time required for achieving a maximum response value is solved according to a real-time response curve, so that the unmarked assessment of the cell aquaporin function condition can berealized. The method can be used for high-throughput screening of correlated targeted AQP drugs.

An assembled battery device comprising a plurality of single cells which are placed with a predetermined space between each of them and an element for detecting swelling is set in the predetermined space between the single cells and operates in accordance with the transformation of the single cells by swelling. Therefore, when a single cell swells and transforms, resulting from being overcharged, the element for detecting swelling is activated in accordance with such transformation and detects the state of overcharging.

The invention belongs to the technical field of agricultural product processing and provides an infrared temperature-control drying method adopting multi-mode ultrasonic pretreatment and used for carrots. The method comprises the steps as follows: fresh carrots in the same size are selected, the selected carrots are cleaned and the cleaned carrots are sliced, and multi-mode ultrasonic pretreatment and infrared temperature-control drying are conducted. The invention aims to overcome the defects that the drying time is long, energy consumption is high, the material heating temperature is unstable, the quality is low and the like in the hot-air drying or infrared drying process. The novel infrared temperature-control drying technology is adopted, material microstructures such as cell rapture, micro-channel formation and cell swelling are changed through multi-mode ultrasonic pretreatment, compared with a method without ultrasonic pretreatment, the method has the advantages that the infrared temperature-control drying efficiency of carrots, the rehydration rate, vitamin C and other quality of dried products are improved, and energy consumption is reduced. The final moisture content of dried carrot slices prepared with the method is controlled at 13% or below, the moisture activity is lower, growth and reproduction of microorganisms are not facilitated, and the dried carrot slices can be preserved for a long term.

An organ protectant solution which is intravenously administered includes a high concentration of cell-impermeant molecules and at least one oncotic agent. The cell-impermeant molecules preferentially load into the interstitial space and the oncotic agent(s) is / are restricted to the vasculature space. Together, they promote transfer of water from cells to interstitium and into the capillaries, thereby preventing or reducing cell swelling, and maintaining blood circulation and oxygenation of tissues. The organ protectant solution extends the “Golden Hour” for traumatic and / or hemorrhagic shock patients, thereby allowing more time for those patients to reach a point of care facility to receive medical treatment.

An organ protectant solution which is intravenously administered includes a high concentration of cell-impermeant molecules and at least one oncotic agent. The cell-impermeant molecules preferentially load into the interstitial space and the oncotic agent(s) is / are restricted to the vasculature space. Together, they promote transfer of water from cells to interstitium and into the capillaries, thereby preventing or reducing cell swelling, and maintaining blood circulation and oxygenation of tissues. The organ protectant solution extends the “Golden Hour” for traumatic and / or hemorrhagic shock patients, thereby allowing more time for those patients to reach a point of care facility to receive medical treatment.

A method to remove cryoprotectants from cryopreserved biological cells and tissues is described. Enzymes are used to convert compounds used as cryoprotectants for cells during cryopreservation to membrane impermeable products. This process effectively removes the cryoprotectant chemicals from the cells prior to their use in transfusion, transplantation, insemination or other applications, without causing osmotic damage due to cell swelling. Methods are described for subsequent removal of the enzymes and enzyme conversion products from the cell and tissue preparations.

The invention relates to isolated organ protection liquid. The protection liquid takes water as a solvent and is prepared from the following components with the mass concentration or the mol concentration: a cell swelling inhibitor with the concentration of 0.8 to 1.6g / L, a cell membrane stabilizing agent with the concentration of 0.01 to 0.015g / L, adenosine with the concentration of 0.005 to 0.008mol / L, allopurinol with the concentration of 0.001 to 0.002mol / L, glutathione with the concentration of 0.001 to 0.005mol / L, an H<+> buffering agent with the concentration of 0.1 to 0.12mol / L and magnesium sulfate with the concentration of 0.003 to 0.006mol / L, wherein the cell swelling inhibitor is prepared from polyvinyl alcohol, potassium hydroxide and sodium hydroxide. Compared with the priorart, the solution viscosity is reduced, a cell membrane is protected and the production cost is reduced.