Chinese brake herb preparation for treating gastrointestinal tract and urinary tract infections and cardiovascular and cerebrovascular diseases and preparation method thereof

A technology for urinary tract infection and cerebrovascular disease, which is applied in the oral series of Pteris vulgaris preparations and its manufacturing field. It can solve the problems of no Pteris vulgaris extract preparation, low dissolution rate and dissolution rate, and large volume of tablets and capsules. Achieve good medication compliance, improved dissolution rate and dissolution rate, and reliable quantification

Inactive Publication Date: 2010-11-24
谢炜 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the hygroscopicity of the total flavonoids and other ingredients in Pteris vulgaris, the dose of the main drug is small, the volume of the tablets and capsules prepared by the traditional method is large, the disintegration time is relatively long, the dissolution rate and dissolution rate are low, and the amount of excipients is large. Children, The elderly, bedridden patients, and patients with dysphagia are inconvenient to take and have poor c...

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0019] prescription:

[0020] Pteris vulgaris extract 2.0g

[0021] Ethyl cellulose 6.0g

[0022] Starch 20g

[0023] Mannitol 20g

[0024] Hydroxypropyl cellulose 20g

[0025] Aspartame 0.5g

[0026] Polysorbate 80 0.1g

[0027] Ethanol

[0028] Magnesium stearate 0.5g

[0029] 1000 pieces

[0030] Preparation method: Dissolve the Pteris vulgaris extract in ethanol. Fully dissolve, add polysorbate 80, stir evenly to become a dispersible ethanol solution of Pteris vulgaris extract, spray into the well-mixed ethyl cellulose, starch, mannitol, hydroxypropyl cellulose, aspartame, Stir fully until it is uniform, add starch slurry to 20 meshes for granulation, dry at 60° C., granulate with 20 meshes, add magnesium stearate and mix uniformly, press and dry to obtain Pteris vulgaris tablets.

example 2

[0032] prescription:

[0033] Pteris vulgaris extract 2.0g

[0034] Sodium Croscarmellose 5.0g

[0035] Micronized silica gel 1.6g

[0036] Mannitol 40g

[0037] Aspartame 0.5g

[0038] Polyvinylpyrrolidone 5g

[0039] Magnesium stearate 1g

[0040] Polysorbate 80 0.1g

[0041] Ethanol

[0042] 1000 pieces

[0043] Preparation method: Dissolve the Pteris vulgaris extract in ethanol. Fully dissolve, add polysorbate 80, stir evenly to become a dispersible ethanol solution of Pteris vulgare, spray into the well-mixed croscarmellose sodium, micronized silica gel, mannitol, polyvinylpyrrolidone and aspartame In the auxiliary materials of the composition, fully stir until uniform, add magnesium stearate and mix uniformly, and directly press the tablets to obtain the Pteris vulgaris orally disintegrating tablets.

example 3

[0045] prescription

[0046] Pteris vulgaris extract 2.0g

[0047] Micronized silica gel 37g

[0048] Mannitol 25g

[0049] Starch 35g

[0050] Polysorbate 80 0.1g

[0051] Ethanol

[0052] Make 1000 capsules

[0053] Preparation method: Dissolve the Pteris officinalis extract in ethanol to fully dissolve it, add polysorbate 80, stir evenly to become a dispersed ethanol solution of Pteris officinalis extract, add the well-mixed micronized silica gel, mannitol, starch and composition In the auxiliary materials, fully stirred until uniform and dry to obtain a dispersion mixture of Pteris sylvestris extract, which is filled into capsules to obtain Pteris sylvestris capsules.

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Abstract

The invention relates to a Chinese brake herb preparation for treating gastrointestinal tract and urinary tract infections and cardiovascular and cerebrovascular diseases and a preparation method thereof. A Chinese brake herb extract is dissolved in a proper solvent by a solvent dispersion method and a solid-liquid phase dispersion melting and dissolving method to prepare Chinese brake herb extract solution; the solution is dispersed and sprayed into an auxiliary material, or is prepared into a uniformly dispersed solid dispersion mixture; and the mixture is crushed, mixed and stirred uniformly, added with a lubricant and tabletted directly, or added with an adhesive, granulated and dried, and added with a lubricant and tabletted. The dispersively mixed particles of the Chinese brake herb extract also can be added with a proper amount of the lubricant and filled into capsules. The preparation is used for treating various symptoms of the gastrointestinal tract and urinary tract infections, also has the effect of treating the cardiovascular and cerebrovascular diseases, and has the advantages of long acting time of the medicament, convenient oral/buccal administration and the like. The Chinese brake herb preparation has the advantages of high content, stable quality, high bioavailability and improvement of the medication compliance of a patient.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and specifically relates to an oral series of Pteris officinalis preparation and a manufacturing method thereof. Background technique [0002] Pteris polyfida extract is a Chinese herbal preparation extracted from the Chinese herbal medicine Pteris multifida Poir. It contains total flavonoids, sterols, amino acids, lactones, and phenols of Pteris multifida Poir. Medicinal ingredients such as sexual substances. With total flavonoids as the main component, the literature records that the Chinese herbal medicine Pongi grass has clearing heat and detoxification, removing dampness, cooling blood, antibacterial and anti-inflammatory effects. It is often used for bacillary dysentery, enteritis, acute and chronic pyelonephritis, cystitis, urinary tract In the treatment of infection, it has been reported in recent literature that the total flavonoids of Pteris vulgaris can treat heart and cerebrovascular dis...

Claims

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Application Information

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IPC IPC(8): A61K36/11A61K9/20A61K9/48A61P1/00A61P13/00A61P31/00A61P9/00A61P9/10
Inventor 谢炜谢金生
Owner 谢炜
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