Thiazole-substituted mercaptoacetamide derivative, preparation method and application thereof

Abstract

The invention belongs to the technical field of medicines, and in particular discloses thiazole-substituted mercaptoacetamide compounds shown as the formula I, N-oxides, stereoisomers, a stereoisomer mixture, pharmaceutically acceptable salts, hydrate thereof, and a solvation matter, polycrystals and eutectics thereof, precursor and derivatives with same biological function, a preparation method thereof and application of a composition containing one or more compounds to treating and preventing human immunodeficiency virus (HIV) and influenza virus infection.

Description

technical field The invention belongs to the technical field of medicine, and in particular relates to a class of substituted thiazole thioethanamide derivatives. The invention also relates to a preparation method of the derivatives and their anti-human immunodeficiency virus (HIV) and anti-influenza virus applications. Background technique Viral infectious diseases are a large class of diseases that seriously endanger human life and health. Human immunodeficiency virus type 1 (HIV-1) is the main pathogen of AIDS (AIDS). Although the current implementation of Highly Active Antiretroviral Therapy (HAART) is a major breakthrough in anti-AIDS treatment, the emergence of drug resistance and the toxicity of long-term medication have greatly limited the application of this therapy, and the development of new anti-AIDS drugs There is no need to delay (see "Research on Anti-AIDS Drugs", edited by Liu Xinyong, People's Medical Publishing House, Beijing, 2006, 12). Influenza virus (...

AI Technical Summary

Problems solved by technology

So far, human beings have been short of safe and effective control methods and preventive drugs against influenza virus, which makes the development of new and efficient anti-influenza virus drugs one of the hot spots in the field of current drug research and development

Images