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Method for preparing pharmaceutic adjuvant film coating material

A coating material and auxiliary material film technology, which can be used in pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve the problems of tablet cracking, coating film cracking, easy elastic recovery, etc. Spray speed, the effect of enhancing toughness

Active Publication Date: 2011-10-05
ANHUI SUNHERE PHARMA EXCIPIENTS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The object of the present invention is to provide a kind of preparation method of film-coating material of pharmaceutical excipient, because the raw material itself contains a large amount of long cellulose and is easy to elastically recover after pressing the tablet, causing the tablet to split from the waist. The cracking of the coating film is a problem that many coating manufacturers cannot solve

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] The present invention is achieved in such a way that a formulation of a pharmaceutical adjuvant film coating material includes the following raw materials in parts by weight: 1.3 parts of hypromellose with a dynamic viscosity of 5mpa.s, hydroxypropyl methylcellulose with a dynamic viscosity of 15mpa.s 2 parts of propyl methylcellulose, 0.5 part of hypromellose with a dynamic viscosity of 50mpa.s, 0.5 part of polyethylene glycol 4000, 0.5 part of talcum powder, 1.3 parts of titanium dioxide, and 85 parts of 80% ethanol with a mass fraction of The preparation method is:

[0014] ①Powder sieve: at room temperature, mix hypromellose with a dynamic viscosity of 5mpa.s, hypromellose with a dynamic viscosity of 15mpa.s, hypromellose with a dynamic viscosity of 50mpa.s, polyethylene glycol Glycol 4000, titanium dioxide, talcum powder passed through a 80-mesh thickening vibrating sieve;

[0015] ② Mixing: At room temperature, weigh the above-mentioned raw materials according to...

Embodiment 2

[0019] The present invention is achieved in this way, a formulation of pharmaceutical adjuvant film coating material includes the following raw materials by weight: 1.6 parts of hypromellose with a dynamic viscosity of 5mpa.s, 1.6 parts of hypromellose with a dynamic viscosity of 15mpa.s 2.4 parts of propyl methylcellulose, 0.7 parts of hypromellose with a dynamic viscosity of 50mpa.s, 0.8 parts of polyethylene glycol 4000, 0.9 parts of talcum powder, 1.6 parts of titanium dioxide, and 92 parts of ethanol with a mass fraction of 80%. The preparation method is:

[0020] ①Powder sieve: at room temperature, mix hypromellose with a dynamic viscosity of 5mpa.s, hypromellose with a dynamic viscosity of 15mpa.s, hypromellose with a dynamic viscosity of 50mpa.s, polyethylene glycol Glycol 4000, titanium dioxide, talcum powder passed through a 80-mesh thickening vibrating sieve;

[0021] ②Mixing: At room temperature, weigh the above-mentioned raw materials according to the required am...

Embodiment 3

[0025] The present invention is achieved in this way, a formulation of a pharmaceutical adjuvant film coating material includes the following raw materials by weight: 2 parts of hypromellose with a dynamic viscosity of 5mpa.s, 2 parts of hypromellose with a dynamic viscosity of 15mpa.s 3 parts of propyl methylcellulose, 1 part of hypromellose with a dynamic viscosity of 50 mpa.s, 40001 parts of polyethylene glycol, 1 part of talcum powder, 2 parts of titanium dioxide, and 95 parts of ethanol with a mass fraction of 80%.

[0026] Its preparation method is:

[0027] ①Powder sieve: at room temperature, mix hypromellose with a dynamic viscosity of 5mpa.s, hypromellose with a dynamic viscosity of 15mpa.s, hypromellose with a dynamic viscosity of 50mpa.s, polyethylene glycol Glycol 4000, titanium dioxide, talcum powder passed through a 80-mesh thickening vibrating sieve;

[0028] ②Mixing: At room temperature, weigh the above-mentioned raw materials according to the required amount ...

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Abstract

The invention provides a pharmaceutic adjuvant film coating material, comprising the following raw materials in parts by weight: 1.3 to 2 parts of hydroxypropyl methylcellulose with dynamic viscosity of 5mpa.s, 2 to 3 parts of hydroxypropyl methylcellulose with dynamic viscosity of 15mpa.s, 0.5 to 1 part of hydroxypropyl methylcellulose with dynamic viscosity of 50mpa.s, 0.5 to 1 part of polyethylene glycol 4000, 0.5 to 1 part of talc powder, 1.3 to 2 parts of titanium powder and 85 to 95 parts of 80 percent ethanol. The pharmaceutic adjuvant film coating material has the advantages of (1) changing the viscosity, elasticity of a film coating and the viscosity of liquid, improving the toughness of the film, and intensifying the adhesion between the film coating and a substrate to reduce the cracking rate of the film coating by improving the formula of the film coating material; (2) changing the coating operation parameters and methods, using 80 percent ethanol solvent as a spray carrier to increase the spray speed, reduce bar temperature, reduce stress in the film, reduce the occurrence rate of film coating cracking, and prevent the phenomenon of substrate adhesion which easily occurs by using water as the carrier.

Description

technical field [0001] The invention relates to a preparation method of a coating material, in particular to a preparation method of a pharmaceutical auxiliary material film coating material. Background technique [0002] Film coating is one of the major achievements in the development of advanced preparation technology in recent years. It is considered to be a technology with strong technology, great difficulty and great impact on product quality. This technology must be based on reliable detection methods and can withstand Practice and the test of time, film coating is a film that wraps polymers outside the solid dosage form, and the film thickness is usually 20-100 microns. Coating materials are divided into gastric-soluble type, enteric-coated type, and sustained-release type according to type. The prescription usually consists of the following components: ①film-forming agent ②plasticizer ③colorant / opacifier ④solvent, the pharmaceutical excipient film coating material ma...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08K3/22A61K47/04A61K47/10A61K47/38C08L71/08C08K3/34C08L1/26
Inventor 徐玉勋朱岩周卫东陈晓雪
Owner ANHUI SUNHERE PHARMA EXCIPIENTS
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