The invention discloses a metal and ceramic bonding agent and a preparation method of the metal and ceramic bonding agent, a CBN grinding wheel and a manufacturing method of the CBN grinding wheel. The metal and ceramic bonding agent is composed of, by mass fraction, 75%-92% of ceramic and 8%-25% of metal. The ceramic is composed of, by mass fraction, 40%-65% of SiO2, 8%-35% of B2O3, 6%-20% of Al2O3, 5%-18% of Na2O5, 0.5%-5% of CaO, 3%-10% K2O, 0.5%-2% of MgO and 2%-6% of TiO2. The metal is composed of, by mass fraction, 55%-80% of Cu, 15%-30% of Sn and 5%-20% of Ni. The metal and ceramic bonding agent can be used as a CBN grinding wheel bonding agent and overcomes the defects that in the grinding process of the ceramic CBN grinding wheel, the surface roughness of a workpiece is large, chatter marks are generated easily, and impact resistance is poor.