Hollow core-shell nanometer mesoporous medicament carrying system with magnetism and luminescent performance, preparation method and application thereof
A technology with luminescent properties and magnetic properties, which can be used in medical preparations of non-active ingredients, preparations for in vivo tests, drug delivery, etc. It can solve the problems of poor thermal and chemical stability, disintegration and release, and achieve water solubility. Good, easy to operate, great application value effect
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Embodiment 1
[0038] Embodiment 1: Preparation of β-FeOOH nanoparticles
[0039] Using hydrothermal method, 4mmol FeCl 3 ·6H 2 O and 1.0 g of polyvinylpyrrolidone (PVP, K-30) were dissolved in 70 mL of deionized water, transferred to a 100 mL stainless steel hydrothermal kettle with a polytetrafluoroethylene liner, and placed in an oven at 100 °C for 10 h. Take it out, cool to room temperature, centrifuge, wash with water three times, and vacuum dry at room temperature for 36 hours to obtain spindle-shaped β-FeOOH nanoparticles.
[0040] The TEM picture of embodiment 1 gained material is as figure 1 As shown, it can be seen from the figure that the average length of nanoparticles is 180nm; the average diameter is 53nm; figure 1 The illustration in (b) is figure 1 Selected-area electron diffraction pattern of a β-FeOOH nanoparticle in (b), showing that the nanoparticle has a single-crystal structure. XRD spectrum as image 3 As shown in (a), it shows that the β-FeOOH nanoparticles obta...
Embodiment 2
[0041] Example 2: The surface of β-FeOOH is coated with SiO containing alkyl chains 2 Preparation of Nanocomposite Core-Shell Materials
[0042] Using the sol-gel method, uniformly disperse 100 mg of β-FeOOH nanoparticles obtained in Example 1 in a mixed solution of 50 mL of water and 250 mL of isopropanol, add 7.5 mL of ammonia water, and then add dropwise a total volume of 0.4 mL of orthosilicon Tetraethyl orthosilicate and octadecyltrimethoxysilane, continue to stir for 3h after adding, then centrifuge, wash the solid with ethanol 3 times, and finally vacuum dry at room temperature for 24h; Tetraethyl orthosilicate and octadecyl The amount of substance ratio of trimethoxysilane was 4.7.
[0043] The TEM picture of embodiment 2 gained material is as figure 2 As shown in (a), it shows that the surface of β-FeOOH obtained in Example 2 wraps SiO containing alkyl chains 2 The composite core-shell nanoparticles have a core-shell structure, and the average thickness of the she...
Embodiment 3
[0044] Example 3: α-Fe 2 o 3 mSiO 2 Preparation of Hollow Nanocomposite Capsules
[0045] The β-FeOOH surface of the obtained β-FeOOH of Example 2 is wrapped with SiO containing alkyl chains 2 The composite core-shell nanoparticles were heat-treated in air at 550 °C for 6 hours to remove the pore-forming agent and transform the inner core from β-FeOOH to α-Fe 2 o 3 , so that a cavity is formed in the inner core to form a hollow nanocapsule structure; the heating rate of the heat treatment is 1° C. / min.
[0046] The TEM picture of embodiment 3 gained material is as figure 2 Shown in (b), show that embodiment 3 gained α-Fe 2 o 3 mSiO 2 The nanocomposite capsule has a cavity structure, and the inner α-Fe 2 o 3 It has a hollow nanocapsule structure, the outer wall of which is tightly attached to the inner wall of mesoporous silica. XRD spectrum as image 3 Shown in (c), show that embodiment 3 gained α-Fe 2 o 3 mSiO 2 The structure of β-FeOOH no longer exists in the...
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