Chiral binaphthyl chromatogram immobile phase, and preparation method and application thereof

Abstract

The invention discloses a chiral binaphthyl chromatogram immobile phase, and a preparation method and application thereof. The Chiral binaphthyl chromatogram immobile phase has a structural formula as shown in the accompanying drawing. The preparation method of the Chiral binaphthyl chromatogram immobile phase comprises the following steps that: the chiral binaphthyl reacts with 3-bromine alkynyl to generate alkynylation dinaphthol, and then the alkynylation dinaphthol reacts with 3-nitrine 3-aminopropyltriethoxy-silane through a clicking chemical method to obtain silane monomers containing chiral binaphthyl units; and the silane monomers are bonded onto the commercial silicon gel to obtain the immobile phase. The invention has the advantages that the structure of the immobile phase is novel, the preparation method is simple and has few steps, the last step of the monomer synthetization is the clicking chemical reaction, and the obtained chiral binaphthyl chromatogram immobile phase can be applied to the chiral binaphthyl chromatogram.

Description

technical field The invention relates to the field of chromatographic stationary phases of chemical technology, in particular to a chiral binaphthyl chromatographic stationary phase and its preparation method and application. Background technique Binaphthalene is a C2 axially asymmetric aromatic compound that has been studied more in recent years. It is easy to split into high-purity enantiomers, and has axial asymmetry and strong plane asymmetry. In addition, the two naphthalene rings on the binaphthyl molecule can provide a strong π-π force. For chromatographic stationary phases containing binaphthyl structures, past researches have mainly focused on the field of chiral chromatography. Among them, the binaphthyl crown ether chiral immobilizers have good resolution ability for chiral amino acids and chiral primary amines [Myung Ho H, Journal of Separation Science. 2006, 29(6), 750-761.]. Also, Oi.S [ Oi S, Shijo M, Tanaka H, ​​Miyano S, Yamashita J, Journal of Chromatogra...

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