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Novel process for decarburizing gentamycin sulfate

A technology of gentamicin sulfate and gentamicin, which is applied in the field of medicine and chemical industry, can solve the problems of many times of carbon removal, low batch yield, and high labor intensity of operation, so as to simplify the process operation and improve the operation environment , the effect of reducing labor intensity

Inactive Publication Date: 2011-04-06
王冰
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The carbon removal process is complicated, the suction and pressure filter equipment is heavy, the operation is labor-intensive, the batch yield is low, the carbon removal is many times, the carbon washing is not thorough, and the activated carbon is used once. At the same time, the concentration of the concentrated solution is required to be high and When the charcoal washing waste liquid is applied, a lot of steam will be wasted, etc.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] Take 1000ml of concentrated solution with a unit of 268,000 u / ml and turn it into salt to form a gentamicin sulfate solution of 223,000 u / ml, heat it to 65°C under a magnetic stirrer, and clean and disinfect the used pipeline facilities; at the same time , rinse 2000ml of activated carbon fixed bed with 3500ml of purified water, then flow salt-transfer solution into activated carbon fixed bed for static adsorption decolorization; collect 940ml of decolorization solution; then top wash with 700ml of purified water and incorporate into the batch; obtain decolorization solution The volume is 1633ml, the unit is 158,000 u / ml, and the carbon removal yield is 96.3%. After charcoal dehydration, filtration and spray drying, the product of gentamicin was obtained, and various indicators met the requirements of "Chinese Pharmacopoeia" 2010 edition after testing.

Embodiment 2

[0024] Take 1000ml of concentrated solution with a unit of 297,000 u / ml and turn it into salt to form a gentamicin sulfate solution of 262,000 u / ml, heat it to 65°C under a magnetic stirrer, and clean and disinfect the pipeline facilities used; at the same time , Rinse 2000ml of activated carbon fixed bed with 3500ml of purified water, and then pour the transsalting solution into the activated carbon fixed bed for static adsorption decolorization; collect 880ml of decolorization solution; then top wash with 800ml of purified water, and incorporate into the batch. The volume of the decolorized solution is 1750ml, the unit is 166,000 u / ml, and the carbon removal yield is 97.8%. After charcoal dehydration, filtration and spray drying, the product of gentamicin was obtained, and various indicators met the requirements of "Chinese Pharmacopoeia" 2010 edition after testing.

Embodiment 3

[0026] Take 1000ml of concentrated solution with a unit of 249,000 u / ml and turn it into salt to form a gentamicin sulfate solution of 206,000 u / ml, heat it to 65°C under a magnetic stirrer, and clean and disinfect the pipeline facilities used; at the same time , 2000ml of activated carbon fixed bed was rinsed with 3500ml of purified water, and then the transsalting solution was flowed into the activated carbon fixed bed for static adsorption decolorization; 905ml of decolorization solution was collected; top washing was carried out with 800ml of purified water, and incorporated into the batch; decolorization solution was obtained The volume is 1700ml, the unit is 142,000 u / ml, and the carbon removal yield is 96.9%. After charcoal dehydration, filtration and spray drying, the product of gentamicin was obtained, and various indicators met the requirements of "Chinese Pharmacopoeia" 2010 edition after testing.

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PUM

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Abstract

The invention relates to a novel process for decarburizing gentamycin sulfate. In the process, a gentamycin sulfate solution subjected to salt conversion can be directly sprayed for drying after being statically adsorbed and decolored by an active carbon fixed bed to obtain a finished product of gentamycin sulfate. The used active carbon can be recycled after being reproduced. The process thoroughly overcomes the defects in the traditional production of the gentamycin sulfate of complicated process of heavy extraction filling press equipment, high labor intensity for operation, lower standardbatch, multiple decarburization operations and the defects that the carbon cannot be thoroughly cleaned and the decolored active carbon cannot be recycled. Meanwhile, the unit of concentrated solution and the consumption of steam can be reduced and the production cost can be effectively reduced; and the novel process has remarkable energy-saving effect.

Description

technical field [0001] The invention belongs to the technical field of medicine and chemical industry, and in particular relates to a process for producing charcoal denovation of gentamicin sulfate. Background technique [0002] At present, in the production process of gentamicin sulfate used at home and abroad—the carbon removal process, the concentrated liquid is converted to salt, then activated carbon is added, the temperature is raised, and the feed liquid is vacuum pumped into the filter press after heat preservation, and then the feed is filtered. ; After the filter press is completed, the purified water top washes the filter; then according to the light transmittance, determine the amount of carbon added for the second carbon removal; then use a large amount of purified water to wash the carbon, concentrate, and then apply it to the next batch. The carbon removal process is complicated, the suction and pressure filter equipment is heavy, the operation is labor-intens...

Claims

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Application Information

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IPC IPC(8): C07H15/236C07H1/06
Inventor 王冰李静仁张新静
Owner 王冰
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