Unlock instant, AI-driven research and patent intelligence for your innovation.
Oxymethylene aryl compounds and uses thereof
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A compound, aryl technology, applied in the field of oxymethylene aryl compound and its use, can solve the problems of elevated, undiscovered PDE cell type selectivity, etc.
Inactive Publication Date: 2011-04-20
CYMABAY THERAPEUTICS
View PDF8 Cites 4 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
The second component is the failure to respond to a hyperglycemic challenge to increase insulin release above an already elevated basal output
Inhibitors of cAMP phosphodiesterases have been shown to increase insulin secretionin vitro and in vivo, including PDE1C, PDE3B, PDE10 (Han P et al., J Biol Chem. 6 Aug 1999; 274(32):22337-44; Harndahl L et al., J Biol Chem. 2002 Oct 4; 277(40):37446-55; WalzHA et al People, J Endocrinol. 2006 Jun;189(3):629-41; Choi YH et al., J Clin Invest. 2006 Dec;116(12) : 3240-51; and Cantin LD et al., Bioorg Med Chem Lett. 2007 May 15; 17(10): 2869-73), but so far, PDEs not found to have the cell-type selectivity necessary to avoid undesired effects
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
[0369]4-(4-Chloromethyl-thiazol-2-yl)-piperidine-1-carboxylic acid tert-butyl ester (intermediate 1,463 mg, 1.46 mmol), 4-methanesulfonyl-phenol (252 mg, 1.46 mmol) and K 2 CO 3 (404 mg, 2.92 mmol) in acetone (25 mL) overnight. After cooling, the solid was filtered through a pad of celite. The filtrate was concentrated in vacuo. The residue was purified on silica gel (EtOAc-hexanes, 1:1) to give the desired product. 1 H NMR (CDCl 3 ): δ7.88 (2H, d, J = 8.8Hz), 7.23 (1H, s), 7.12 (2H, d, J = 8.8Hz), 5.24 (2H, s), 4.21 (2H, br), 3.17 (1H, m), 3.04 (3H, s), 2.88 (2H, m), 2.11 (2H, m), 1.73 (2H, m), 1.47 (9H, s).
[0378] 1 H NMR (DMSO-d 6 ): δ9.77(1H, s), 7.57(1H, s), 7.45(2H, d, J=9.0Hz), 6.94(2H, d, J=9.0Hz), 5.04(2H, s), 3.98 (2H, m), 3.18 (1H, m), 2.82 (2H, m), 2.02 (2H, m), 1.99 (3H, s), 1.51 (2H, m), 1.39 (9H, s).
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Login to View More
Abstract
Use of oxymethylene aryl GPR119 agonists and DPP IV inhibitors for the treatment of diabetic diseases, including Type II diabetes and other diseases associated with poor glycemic control are provided.
Description
Background technique [0001] Diabetes can be divided into two clinical syndromes: type I diabetes and type II diabetes. Type I diabetes or insulin-dependent diabetes mellitus is a chronic autoimmune disease characterized by insulin-producing beta-cells (hereinafter referred to as "islet cells" or "islet cells") in the islets of Langerhans of the pancreas. ) are lost in large numbers. As these cells are progressively destroyed, the amount of insulin secreted decreases, eventually leading to hyperglycemia (abnormally high levels of glucose in the blood) when the amount secreted falls below that required for euglycemia (normal levels of blood sugar). content). Although the exact trigger of this immune response is unknown, type 1 diabetics have high levels of antibodies directed against pancreatic β-cells (hereinafter referred to as "β-cells"). However, not all patients with high levels of these antibodies develop type 1 diabetes. [0002] Type II diabetes, or non-insulin depen...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
Login to View More 
Login to View More