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Injectable efficient suspended stable calcium phosphate cement and preparation method and application thereof

A technology of calcium phosphate bone cement and suspension stabilizer, which is applied in dental preparations, pharmaceutical formulations, medical science, etc., and can solve the problems of prolonging the curing time, reducing the injectability of calcium phosphate bone cement, and poor suspension stability

Active Publication Date: 2014-07-09
EAST CHINA UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0012] The primary purpose of the present invention is to overcome the disadvantages of poor suspension stability in the prior art of injectable non-aqueous calcium phosphate bone cement, separation of solid and liquid phases after long-term storage, reduction of injectability of calcium phosphate bone cement and prolongation of curing time, etc., to provide a A kind of preparation method of injectable high-efficiency suspension stable calcium phosphate bone cement

Method used

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  • Injectable efficient suspended stable calcium phosphate cement and preparation method and application thereof
  • Injectable efficient suspended stable calcium phosphate cement and preparation method and application thereof
  • Injectable efficient suspended stable calcium phosphate cement and preparation method and application thereof

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preparation example Construction

[0073] A preparation method for injectable high-efficiency suspension-stable calcium phosphate bone cement, comprising the following steps:

[0074] (1) Preparation of injectable high-efficiency suspension stable calcium phosphate bone cement solidification solution

[0075] The stabilizer is added to the non-aqueous phase solution, and the solidified liquid is obtained by ultrasonic dispersion according to the mass ratio of non-aqueous phase solvent:suspension stabilizer=10:(0.1-1).

[0076] Wherein said non-aqueous solvent is at least one of simethicone, propylene glycol, water-soluble silicone oil, glycerin and polyethylene glycol (including one solvent, or a mixed solvent composed of multiple solvents).

[0077] Wherein said suspension stabilizer is at least one of hydrophilic silicon dioxide, hydrophobic silicon dioxide and surface-modified silicon dioxide. Surface-modified silica refers to fumed silica that has been treated by dry method, wet method or dry heat method. ...

Embodiment 1

[0102] Weigh 10 g of composite calcium phosphate salt (ingredients: calcium hydrogen phosphate, tetracalcium phosphate and hydroxyapatite) powder with an average particle size less than 10 μm, and 1 g of iodoform, and dry mix to form a solid phase powder;

[0103] Weigh 0.15 g of hydrophilic fumed silica (average particle diameter: 30 nm), pour it into a beaker containing 6 g of propylene glycol, and stir fully so that the hydrophilic fumed silica is fully dissolved in propylene glycol to obtain a solidified solution.

[0104] Pour the solidified liquid into the powder, disperse evenly in the vessel, and mix evenly with a dental spatula to obtain a non-aqueous calcium phosphate bone cement with good developability and injectability (referred to as "bone cement paste").

[0105] The prepared non-aqueous calcium phosphate bone cement was filled into a 5ml syringe and left to stand. The time elapsed from the beginning of standing to the time when the bone cement in the syringe cl...

Embodiment 2

[0112] Weigh 10 g of composite calcium phosphate salt (ingredients: calcium hydrogen phosphate, tetracalcium phosphate and hydroxyapatite) powder with a particle size less than 10 μm, 1 g of strontium chloride, and 0.15 g of hydrophobic fumed silica (average particle size of 20 nm), Dry mixing; pour into a beaker containing 6g of simethicone oil, and ultrasonically disperse to fully dissolve the hydrophobic fumed silicon dioxide into the simethicone oil, disperse evenly in the vessel, and mix evenly with a dental preparation knife to obtain Non-aqueous calcium phosphate bone cement with good visualization and injectability (see appendix image 3 ).

[0113] The prepared non-aqueous calcium phosphate bone cement was filled into a 5ml syringe and left to stand. The time elapsed from the beginning of standing to the time when the bone cement in the syringe clearly delaminated was taken as the suspension stability time of the system.

[0114] The bone cement paste prepared above...

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Abstract

The invention relates to injectable efficient suspended stable calcium phosphate cement and a preparation method and application thereof. The invention discloses the injectable efficient suspended stable calcium phosphate cement and the preparation method and the application thereof. When fumed silica and a modified product thereof are applied in the injectable calcium phosphate cement, the suspension stability of the original calcium phosphate cement is remarkably improved, the curing property of the calcium phosphate cement is kept on the basis that the operation is simple and convenient, and meanwhile the requirements of the injectable property and the compressive strength of the calcium phosphate cement are not reduced. The calcium phosphate cement has the advantages of low raw material cost, simple preparation, convenience for operation and the like, has good suspension stability, can be stored for a long term under certain conditions, and is expected to be used as a high-performance novel tissue repair material which realizes large-scale industrialized production and is applied to clinic.

Description

technical field [0001] The invention belongs to the field of medical materials for repairing tissue damage, and in particular relates to an injectable high-efficiency suspension stable calcium phosphate bone cement and its preparation method and application. Background technique [0002] With the progress of society and the development of science, people's requirements for medical level are getting higher and higher. Safer and more effective treatment methods and means are the goals that medical workers and material researchers are constantly striving to pursue. Injectable tissue repair materials can be directly injected into the defect site through a syringe for precise filling and repair, achieving minimally traumatic or even non-invasive treatment, and have broad application prospects in the repair of bone and tooth defects, plastic surgery, and beauty. This injection treatment method not only overcomes the defects of large trauma and high incidence of surgical complicati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/50A61L31/02A61L31/18A61K6/033A61K6/027A61K6/838
Inventor 刘昌胜陈芳萍毛昱浩
Owner EAST CHINA UNIV OF SCI & TECH
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