Use of dronedarone or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in regulating the potassium level in the blood

A technology of dronedarone and medicinal salts, applied in drug combinations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the problem of lack of antiarrhythmic drugs

Inactive Publication Date: 2011-05-18
SANOFI AVENTIS SA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0023] To date, no antiarrhythmic drug has demonstrated an effect on the regulation of blood potassium levels in treatment

Method used

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  • Use of dronedarone or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in regulating the potassium level in the blood

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0083] By dronedarone hydrochloride, in a prospective, multi-ethnic, multicenter, double-blind clinical study, two treatment groups (with dronedarone salt) in patients with a history of atrial fibrillation or atrial flutter The efficacy of dronedarone and its pharmaceutically acceptable salts compared to placebo in preventing cardiovascular hospitalization or preventing death was demonstrated.

[0084] I. Patient Selection

[0085] Eligible patients must have a history of atrial fibrillation or flutter and / or be able to exhibit normal sinus rhythm or atrial fibrillation or flutter.

[0086] The recruitment of patients considered the following selection criteria:

[0087] selection criteria :

[0088] 1) One of the following risk factors must exist:

[0089] - Age equal to or greater than 70, or even greater than 75, possibly combined with at least one of the following risk factors:

[0090] ○High blood pressure (taking at least two different types of antihypertensive dru...

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Abstract

Use of dronedarone or a pharmaceutically acceptable salt thereof, for the preparation of a medicament for use in regulating the potassium level in the blood.

Description

technical field [0001] The invention relates to the use of dronedarone or a pharmaceutically acceptable salt thereof in the preparation of medicines for regulating blood potassium levels. Background technique [0002] 2-n-Butyl-3-[4-(3-di-n-butylaminopropoxy)benzoyl]-5-methylsulfonamidobenzofuran or Dronedarone, and their pharmaceutically acceptable salts. [0003] Dronedarone blocks potassium, sodium and calcium ion channels and has antiadrenergic properties. [0004] Dronedarone is an antiarrhythmic drug that is effective in maintaining sinus rhythm in patients presenting with atrial fibrillation or atrial flutter. [0005] Specifically, this ion is the main osmoticallt active intracellular ion and plays an important role in the regulation of intracellular volume. [0006] A constant and stable concentration of potassium ions is important for the function of the enzyme system and for good growth and cell division. [0007] Potassium contributes to the establishment of ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/343A61P9/04
CPCA61K31/343A61P3/00A61P3/12A61P43/00A61P9/00A61P9/04A61P9/06A61P9/10A61P9/12A61P3/10
Inventor 戴维·拉德齐克马丁·范艾克尔斯克里斯托夫·高丁纳西拉·哈姆达尼
Owner SANOFI AVENTIS SA
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