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Levetiracetam oral disintegrating tablet and preparation method thereof

A kind of oral disintegrating tablet and technology of disintegrating tablet, applied in the field of levetiracetam oral disintegrating tablet and preparation field thereof

Active Publication Date: 2011-06-08
BEIJING YILING BIOENG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The exact antiepileptic mechanism of levetiracetam is unknown, but it is different from traditional antiepileptic drugs in ion channels or excitatory and inhibitory neurotransmitter systems

Method used

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  • Levetiracetam oral disintegrating tablet and preparation method thereof
  • Levetiracetam oral disintegrating tablet and preparation method thereof
  • Levetiracetam oral disintegrating tablet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Weight ratio of raw and auxiliary materials:

[0050] Levetiracetam 2500g, polyethylene glycol 60005000g, maltodextrin 1000g, hydrolyzed gelatin 20g.

[0051] 2. The preparation method of levetiracetam orally disintegrating tablets according to claim 1, characterized in that levetiracetam orally disintegrating tablets are prepared through the following steps:

[0052] (a) Preparation of dispersion: Weigh polyethylene glycol 6000 and levetiracetam in proportion, heat and melt polyethylene glycol 6000 and add levetiracetam, stir well, fully cool, and pulverize through 100 mesh Sieve to get the levetiracetam dispersion for subsequent use;

[0053] (b) Ingredients: dissolving the hydrolyzed gelatin into a 0.5% aqueous solution, adding the levetiracetam dispersion and maltodextrin obtained in step (a) in proportion, and fully stirring to obtain a mixed material;

[0054] (c) Freeze-drying: put the mixed material obtained in step (b) into a suitable mold, and after pre-free...

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Abstract

The invention provides a levetiracetam oral disintegrating tablet and a preparation method thereof. The levetiracetam oral disintegrating tablet is prepared by adopting a freeze drying process and contains levetiracetam as an active constituent, polyethylene glycol 6000 as a solid dispersing agent, maltodextrin as a freeze-drying protective agent and hydrolyzed gelatin as an adhesive. The levetiracetam is a novel antiepileptic drug, and the levetiracetam oral disintegrating tablet provided by the invention has the advantage of improving the medication compliance of patients and the curative effect.

Description

technical field [0001] The invention relates to a levetiracetam orally disintegrating tablet and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. Background technique [0002] Epilepsy is a chronic disease in which the sudden abnormal discharge of brain neurons leads to transient brain dysfunction. Epileptic seizure refers to the clinical phenomenon caused by abnormal and excessive supersynchronized discharge of brain neurons. Transient symptoms vary depending on where in the brain the abnormally firing neurons are located and can be motor-sensory-mental or autonomic with or without changes in consciousness or alertness. [0003] Levetiracetam (Levetiracetam) is a new type of oral antiepileptic drug, which has a different structure from other antiepileptic drugs and has a new antiepileptic mechanism. The exact antiepileptic mechanism of levetiracetam is unknown, but it is different from traditional antiepileptic drugs in acting ...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K31/4015A61K47/42A61P25/08A61K47/10A61K47/36
Inventor 田书彦
Owner BEIJING YILING BIOENG
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