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Preparation technology of new integrative formulation of baical skullcap root decoction and production method thereof

A production method and integrated technology, applied in antiviral agents, drug combinations, pharmaceutical formulations, etc., to achieve the effect of wide targeted distribution

Inactive Publication Date: 2011-06-22
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are no identical or similar literature reports at home and abroad

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] The following raw materials are prepared according to the aforementioned method: extracts, nanoparticles, microcapsules, and nanoparticles.

[0043]The composition of the raw materials used to make the active ingredients is——

[0044] 9 parts of skullcap, 9 parts of peony, 6 parts of licorice, 4 parts of jujube.

[0045] Its manufacturing process is as follows:

[0046] In the GMP10000 clean room, the extract, nanoparticles, microcapsules, and nanoparticles are mixed according to the ratio of 4:2:2:2, and the latest version of the "Chinese Pharmacopoeia" preparation part of the hard capsule standard is adopted, without adding excipients, antiseptic The preparation is filled with hard capsules by a full-automatic capsule filling machine to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch uniform instant sterilization, and issue a steri...

Embodiment 2

[0048] Prepare the following raw materials according to the aforementioned method: water decoction concentrate, nano liposome, nanoemulsion, microemulsion, nano suspension.

[0049] The composition of the raw materials used to make the active ingredients is——

[0050] 9 parts of skullcap, 9 parts of peony, 6 parts of licorice, 4 parts of jujube.

[0051] Its manufacturing process is as follows:

[0052] In the GMP10000 clean room, the decoction concentrate, nanoliposome, nanoemulsion, microemulsion, and nanosuspension are mixed according to the ratio of 5:1:1:2:1, and the latest version of "Chinese Pharmacopoeia" is used. Part of the soft capsule standard, without adding auxiliary materials and preservatives, adopts a fully automatic soft capsule filling machine to sub-pack soft capsules to make soft capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch un...

Embodiment 3

[0054] Prepare the following raw materials according to the aforementioned method: extract, solid lipid nanoparticles, and nanoemulsion.

[0055] The composition of the raw materials used to make the active ingredients is——

[0056] 9 parts of skullcap, 9 parts of peony, 6 parts of licorice, 4 parts of jujube.

[0057] Its manufacturing process is as follows:

[0058] In the GMP10000 clean room, the extract, solid lipid nanoparticles, and nanoemulsions are mixed in a ratio of 4:3:3, and the latest version of the "Chinese Pharmacopoeia" preparation part of the film standard is adopted, and the film-forming material is polyvinyl alcohol. Made into a film. Cartoning, sealing, sticking labels, printing codes, packing and other internal and external packaging. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report. The area of ​​each film is 2-40 square centimeters, the drug content is 1.2-5 grams, and each film is applied for...

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Abstract

The invention relates to a preparation technology of a new integrative formulation of baical skullcap root decoction and a production method thereof. The baical skullcap root decoction comprises the following raw materials in part by weight: 9 parts of baical skullcap root, 9 parts of Chinese herbaceous peony, 6 parts of liquoric root and 4 parts of Chinese date. The production process comprises the following steps of: alcohol / water extracting, ultrasonic crushing extracting, microwave extracting, decocting and concentrating, spray drying, high-pressure homogenizing, nanometer grinding, nanometer particle preparation and the like. The preparation technology and the production method have the advantages of multi-synergetic effect, multi-targeting effect and the like of nanometer traditional Chinese medicines. By the large-scale industrial production, the production cost can be reduced substantially, the quality of products can be improved, and the targeting and slow controlled release properties of medicaments are high; and a prepared membrane agent also can be applied to the skin of human bodies for treatment by transdermal absorption.

Description

technical field [0001] The invention relates to a preparation technology of a new integrated dosage form of Huangqin Decoction, and also relates to a preparation technology of a new integrated dosage form of Huangqin Decoction and a production method thereof. Background technique [0002] The relevant laws and regulations on drug management in my country stipulate that changing dosage forms is managed as a new drug research. [0003] Traditional Chinese medicine compound prescription embodies the holistic view, system theory, and syndrome differentiation and treatment principles of traditional Chinese medicine treatment, which emphasizes strengthening the body and eliminating pathogenic factors, and treating both symptoms and root causes. What a single ingredient can sum up. The efficacy of the compound medicine is not only related to the active substances or groups of effective substances, but also related to the auxiliary components. When the traditional Chinese medicine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/725A61K9/00A61P1/00A61P1/04A61P1/12A61P31/04A61P31/12A61P33/02
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
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