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High-accuracy surface plasmon resonance (SPR) detection method

A surface plasmon and resonance detection technology, which is applied in the field of sensors and sensing, can solve the problems of SPR sensing information accuracy, sampling density limitation, etc., and achieve the goal of improving accuracy and detection limit, improving detection limit, and eliminating position uncertainty. Effect

Inactive Publication Date: 2011-06-22
BEIHANG UNIV
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Problems solved by technology

[0013] On the other hand, the accuracy of SPR sensing information is also limited by the sampling density of the SPR curve

Method used

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  • High-accuracy surface plasmon resonance (SPR) detection method
  • High-accuracy surface plasmon resonance (SPR) detection method
  • High-accuracy surface plasmon resonance (SPR) detection method

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Embodiment Construction

[0040] The invention provides a high-precision SPR sensing detection method. By acquiring low-sampling density SPR curves with micro-translation multiple times under the same experimental conditions and estimating the relative micro-translation between them, an expected absolute position vector is further estimated, and then by fusing multiple low-sampling density SPR curves with micro-translation Based on the different information between the curves, a more accurate and higher sampling density sensing curve is estimated within the position range corresponding to the expected absolute position vector, thereby improving the accuracy of the obtained SPR sensing information and the detection limit of the SPR system.

[0041] figure 1 A flowchart of the detection method is given, which mainly includes five steps of multiple SPR signal acquisition 101, micro-translation estimation 102, expected absolute position vector estimation 103, information fusion 104, and SPR information ext...

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Abstract

The invention discloses a high-accuracy surface plasmon resonance (SPR) detection method. In the method, signal acquisition is performed on the same SPR detection system for multiple times under the same experimental condition to acquire a plurality of SPR curves with micro random translation, relative micro translation among the plurality of SPR curves is estimated, and an expected absolute position vector is further estimated on the basis, so that position uncertainty in the acquisition process of the SPR curves is avoided; meanwhile, by fusing different information among the plurality of SPR curves with the micro translation, a more accurate SPR curve with higher sampling density is acquired through estimation at the expected absolute position, so that the accuracy of the acquired SPR sensing information and the detection limit of an SPR system are improved.

Description

technical field [0001] The invention relates to the field of sensors and sensing technology. The invention specifically relates to a detection method for realizing surface plasmon resonance sensing and a related information processing method. Background technique [0002] Surface plasmon resonance (Surface Plasmon Resonance, SPR) is a physical optical phenomenon that occurs at the interface between metal thin films and dielectrics. It is widely used in sensing, especially in the field of biosensing. [0003] SPR sensing system includes optical system, sensing structure, detector and data processing system, etc. In the optical system, the P-polarized light output from the light source is coupled into the sensor through certain optical elements. The most widely used and most easily implemented SPR coupling structure is the Kretschman structure based on prism coupling. Its typical structure includes three layers: glass prism - metal layer - solution layer to be measured. ...

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Application Information

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IPC IPC(8): G01N21/55G01N21/552
Inventor 郑铮曾勰万育航
Owner BEIHANG UNIV
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