Mixed compound medicament of natural medicament components and nitric oxide donors and application thereof
A technology of nitric oxide and natural medicine, applied in the field of anti-tumor drugs and their medical applications, can solve the problem of insufficient effect, avoid toxic and side effects, enhance anti-tumor activity and selectivity, and highlight dual-effect inhibition of diseased cell activity Effect
Inactive Publication Date: 2011-06-29
CHIFCON DRUG DISCOVERY SUZHOU
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Problems solved by technology
However, most of the current natural anti-tumor drugs are not strong enough, which limits their further application.
Method used
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Embodiment
[0063] Taking the mixed compound drug of ursolic acid and nitric oxide donor as a specific example, its biological test of inhibiting tumor cell growth is described in detail:
[0064] The nitric oxide donor was prepared by chemical synthesis, and a mixed compound preparation was made with ursolic acid in a certain proportion, and then the mixed compound preparation was tested by the international standard MTT method with ursolic acid as a control Inhibitory activity on tumor cell growth, but this is not meant to limit the present invention.
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Abstract
The invention discloses a mixed compound medicament of natural medicament components and nitric oxide donors. The mixed compound medicament is characterized in that: the mixed compound medicament is obtained by compounding at least one natural medicament component and at least one nitric oxide donor in any mass concentration ratio, wherein the natural medicament component is a medicinal material with antitumor activity; and the nitric oxide donor is a compound with the ability of releasing nitric oxide. After the mixed compound medicament of the natural medicament components and the nitric oxide donors is applied, the antitumor activity and selectivity of the natural medicament components can be effectively strengthened, and the toxic or side effect of non-natural medicaments can be avoided; meanwhile, the antitumor activity of the nitric oxide is played, so the mixed compound medicament has the ability of remarkable double-effect inhibition on the activity of pathological cells, and can be widely and effectively applied in the treatment of cancer.
Description
technical field [0001] The present invention relates to a class of anti-tumor drugs and their medical applications, in particular to a class of mixed compound drugs capable of enzymatically releasing nitric oxide free radicals in vivo and enhancing the anti-tumor activity of natural drugs, which can be used to prepare drugs for treating tumors, cancers and other diseases. drug. Background technique [0002] Nitric oxide (hereinafter abbreviated as NO), as a free radical gas, is a low molecular weight and hydrophobic bioactive molecule in the human body, which can freely pass through the cell membrane and act on target molecules in the cell. In theory, nitric oxide can reach any part of cells and tissues, and can regulate various cell functions and produce a wide range of biological effects in vivo. Therefore, nitric oxide donors and regulators have important application value in the research and development of new drugs. [0003] Recent studies have found that human and oth...
Claims
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Patent Timeline
Login to View More IPC IPC(8): A61K45/06A61P35/00
CPCA61K36/00A61K45/06A61K31/4245A61K31/34A61K31/21A61K9/20A61P35/00A61K2300/00
Inventor 冯子侠刘晓东
Owner CHIFCON DRUG DISCOVERY SUZHOU