Multi-epitope artificial antigen of plasmodium falciparum and application thereof

A technology of Plasmodium falciparum and its application, which is applied in the field of immune preparations against Plasmodium falciparum infection and the preparation of diagnostic reagents for Plasmodium falciparum infection, can solve problems such as antigenic variation, and achieve the effect of high inhibition efficiency and high immunogenicity
CN102108355AActive Publication Date: 2011-06-29THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
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Patent Information

Authority / Receiving Office
CN Β· China
Current Assignee / Owner
THE INST OF BASIC MEDICAL SCI OF CHINESE ACAD OF MEDICAL SCI
Publication Date
2011-06-29

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Abstract

The invention relates to a multi-epitope artificial antigen of plasmodium falciparum and an application thereof. The invention designs a polynucleotide with a sequence as shown in SEQ ID No:1 and a polypeptide with a sequence as shown in SEQ ID No:2, wherein the polynucleotide and the polypeptide are used as artificial antigens to prepare vaccines, and antibodies can be obtained from the antigens and are used to prepare immune preparations against plasmodium falciparum infections and kits for detecting malaria infections. Compared with anti plasmodium falciparum vaccines in the prior art, the multi-epitope artificial antigen of the invention has high immunogenicity and antigen recognition diversity, and the antibody of the invention has high inhibition efficiency on the in vitro growth of plasmodium falciparum.
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Description

technical field

[0001] The invention relates to the field of development and application of genes in biomedical high technology. Specifically, the present invention relates to an amino acid sequence of an artificial antigen with multiple epitopes that can be recognized by the serum of patients with falciparum malaria and a polynucleotide sequence encoding the amino acid sequence. The present invention also relates to a vaccine containing said amino acid sequence or said polynucleotide sequence. The present invention further relates to the use of the artificial antigen in the preparation of diagnostic reagents for Plasmodium falciparum infection and immune preparations against Plasmodium falciparum infection. Background technique

[0002] Malaria is one of the deadliest epidemics in the world today. Nearly 4 billion people live in malaria-endemic areas worldwide, with approximately 247 million new infections each year and approximately 1 million deaths per year. Among the ...

Claims

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