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Longhairy antenoron herb and common threewingnut root Chinese medicinal composition with effect of preventing and treating cancer and application thereof

A technology of Tripterygium wilfordii and Desmodium, applied in the field of medicine, can solve the problems of hepatotoxicity and enhanced anticancer activity of Tripterygium wilfordii

Inactive Publication Date: 2011-07-06
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although Desmodium has good hepatoprotective activity, there are no public reports on whether its combined application with Tripterygium wilfordii can reduce the hepatotoxicity induced by Tripterygium wilfordii and whether it can enhance the anticancer activity of tripterygium wilfordii

Method used

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  • Longhairy antenoron herb and common threewingnut root Chinese medicinal composition with effect of preventing and treating cancer and application thereof
  • Longhairy antenoron herb and common threewingnut root Chinese medicinal composition with effect of preventing and treating cancer and application thereof
  • Longhairy antenoron herb and common threewingnut root Chinese medicinal composition with effect of preventing and treating cancer and application thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0010] In practice, the present invention is made by mixing Tripterygium wilfordii extract and Desmodium extract in percentage by weight: 40% of Tripterygium wilfordii extract and 60% of Desmodium extract, wherein said Tripterygium wilfordii extract Tripterygium wilfordii is crushed, extracted 3 times, each time with 10 times the weight of Tripterygium wilfordii and extracted with 75% ethanol for 2 hours, after combining the filtrates for 3 times, concentrated under reduced pressure to a concentration equivalent to 1 g / mL of crude drug; The described desmodium extract is that after desmodium is crushed, it is extracted 3 times, and each time it is extracted with 10 times the mass concentration of 75% ethanol for 2 hours. Concentration 1g / mL;

Embodiment 2

[0012] The present invention is by tripterygium active ingredient (extract) and Desmodium active ingredient (extract) in percentage by weight in practice: Tripterygium active ingredient (extract) 50%, Desmodium active ingredient (extract) 50% %, mixed together and made, wherein the active ingredient (extract) of Tripterygium wilfordii is pulverized, extracted 3 times, extracted 2 hours each time with ethyl acetate of 10 times the weight of Tripterygium wilfordii, combined 3 times After the filtrate, concentrate under reduced pressure to be equivalent to containing the concentration of crude drug 1g / mL; Described desmodium active ingredient (extract) is after Desmodium is pulverized, extracts 3 times, each time extracts 2 with 10 times of ethyl acetate. hour, after merging the filtrate for 3 times, concentrate under reduced pressure to be equivalent to containing crude drug concentration 1g / mL;

Embodiment 3

[0014] The present invention is in practice by tripterygium active ingredient (extract) and Desmodium active ingredient (extract) in percentage by weight: Tripterygium active ingredient (extract) 60%, Desmodium active ingredient (extract) 40% %, mixed together to make, wherein the active ingredient (extract) of Tripterygium wilfordii is pulverized, extracted 3 times, extracted 2 hours with water of 10 times the weight of Tripterygium wilfordii each time, after merging the filtrate for 3 times , concentrated under reduced pressure to be equivalent to containing crude drug concentration 1g / mL; Described desmodium herbaceous active ingredient (extract) is after desmodium desmodium is pulverized, extracts 3 times, extracts 2 hours each time with 10 times the amount of water, merges 3 After the first filtrate, concentrate under reduced pressure to be equivalent to containing crude drug concentration 1g / mL;

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PUM

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Abstract

The invention relates to a longhairy antenoron herb and common threewingnut root Chinese medicinal composition with the effect of preventing and treating cancer and application thereof, which can effectively solve the medicine administration and treatment problems of cancer. The Chinese medicinal composition is prepared by taking common threewingnut root and longhairy antenoron herb as Chinese herbal medicines, and by steps of crushing and mixing 40 to 80 weight percent of common threewingnut root powder and 20 to 60 weight percent of longhairy antenoron herb powder together, or is prepared from 40 to 80 weight percent of active ingredients of the common threewingnut root and 20 to 60 weight percent of active ingredients of the longhairy antenoron herb. The composition is a broad-spectrum medicine for treating the cancer, can be effectively used for treating gastric cancer, liver cancer, breast cancer, esophageal cancer, pancreatic cancer, lung cancer, bladder cancer, ovarian cancer, prostatic cancer, colorectal cancer, colon cancer, skin cancer, thyroid cancer, cervical carcinoma and leukemia, and represents an innovation in medicines for treating the cancer.

Description

technical field [0001] The invention relates to medicine, in particular to a traditional Chinese medicine composition of desmodium and tripterygium wilfordii with the functions of preventing and treating cancer and its application. Background technique [0002] Cancer is one of the major diseases that seriously threaten human health and life. In the treatment of cancer, although the traditional radiotherapy and chemotherapy have made great progress, because it kills cancer cells, it also produces different degrees of toxic side effects on the human body, mainly bone marrow suppression and low immune function. Cause leukopenia, etc., sometimes even have to interrupt treatment, which also limits the efficacy of drugs. In order to overcome a series of ills caused by traditional radiotherapy and chemotherapy, pharmaceutical workers have been exploring continuously in recent years, and the application of herbal medicines to prevent and treat cancer has become a hot research fiel...

Claims

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Application Information

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IPC IPC(8): A61K36/37A61P35/00A61P35/02
Inventor 王君明崔瑛
Owner HENAN UNIV OF CHINESE MEDICINE
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