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Method for preparing degradable polymer microspheres with controllable grain size

A technology for degrading polymers and polymers, applied in medical science, block delivery, prostheses, etc., can solve the problems of polymer micellar particles that are difficult to degrade and cannot be used in the body, and achieve good biocompatibility and biological The effect of degradability

Inactive Publication Date: 2011-07-20
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method can improve the stability of polymeric micelles, the cross-linked polymeric micelles are difficult to degrade, so they cannot be used in vivo

Method used

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  • Method for preparing degradable polymer microspheres with controllable grain size
  • Method for preparing degradable polymer microspheres with controllable grain size
  • Method for preparing degradable polymer microspheres with controllable grain size

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Weigh 5.264g (14mmol) of lithocholic acid, 1.08g (6mmol) of caffeic acid, 0.009g (0.1mmol) of sodium acetate, and 12ml of acetic anhydride, add them to a 250ml reactor, and heat up to 140°C at a stirring speed of 300r / min , reacted for 2 hours, and finally raised the temperature to 200° C., stirred and reacted at constant temperature for 6 hours, and the whole reaction was carried out under nitrogen protection and light-shielding conditions. Wash twice with deionized water, reprecipitate twice in ethanol, and then dry at constant temperature at 30°C to obtain a polymer product. The structure of the resulting polymer is:

[0027]

[0028] m=10-400, n=10-300, expressed as P(LCA-co-DHCA).

[0029] Dissolve the polymer in N,N-dimethylformamide (DMF) to form a 2mg / ml solution, take 5ml of the polymer solution, and -1 Slowly add 5ml of ultra-pure water to the polymer solution under stirring, stir at room temperature for 12 hours, add ultra-pure water 10 times of the solu...

Embodiment 2

[0031] Except 3.76g (10mmol) of lithocholic acid, 1.80g (10mmol) of caffeic acid, other is identical with embodiment 1.

Embodiment 3

[0033] Weigh 2.256g (6mmol) of lithocholic acid and 2.52g (14mmol) of caffeic acid, the others are the same as in Example 1.

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Abstract

The invention discloses a method for preparing degradable polymer microspheres with controllable grain size, and belongs to the field of functional materials. The method comprises the following steps of: preparing polymer from raw materials of biological monomers derived from animals and plants such as lithocholic acid (LCA), cholic acid (CA), 3,4-dihydroxycinnamic acid (DHCA), 4-hydroxycinnamic acid (4HCA) and the like, self-assembling the polymer under certain condition to obtain microspheres, and crosslinking and curing through ultraviolet. The microspheres have excellent biocompatibility and biodegradability; and the grain size of the microspheres, degrading speed, and ultraviolet crosslinking degree can be controlled by adjusting the rate of charge. The polymer microspheres are applied to the fields such as medicine sustained-release systems, tissue engineering, environmental protection and the like.

Description

technical field [0001] The invention discloses a method for preparing degradable polymer microspheres with controllable particle size, which belongs to the field of functional materials. Background technique [0002] At present, polymer micellar particles have been widely used as a new type of carrier in the fields of biomedicine and environmental protection. Drug sustained-release carriers based on polylactic acid or polylactic acid vinyl alcohol copolymers have been used clinically because of their good biocompatibility and biodegradability. US Patent No. 5,429,826 discloses a di- or multi-block copolymer comprising hydrophilic polyalkylene glycol and hydrophobic polylactic acid. The above-mentioned patents disclose the preparation technology of polymer micelles, in which di- or multi-block copolymers with acrylic acid end groups are micellized in an aqueous solution, and then cross-linked to fix the micellar particles. Although this method can improve the stability of p...

Claims

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Application Information

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IPC IPC(8): C08J3/24C08J3/16C08J3/28C08G63/06A61K9/16A61K47/34A61L27/18
Inventor 施冬健陈明清李会玲东为富倪忠斌赵继石
Owner JIANGNAN UNIV
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