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Preparation method of medical polyether-ether-ketone material modified by lac mixed solution

A polyether ether ketone and mixed solution technology, applied in the fields of medical science, prosthesis, coating, etc., can solve the problems of easy peeling, reduced mechanical properties of PEEK substrate, poor coating adhesion, etc., to achieve mechanical properties matching. Good, good biocompatibility and biodegradability, good binding properties

Active Publication Date: 2022-01-11
THE THIRD AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in these methods, adding biologically active substances to the PEEK matrix will greatly reduce the mechanical properties of the PEEK matrix; and the method of surface modification using plasma injection and magnetron sputtering, because the bonding mode of the coating is by physical bonding, so The prepared coating has poor adhesion and is prone to peeling off

Method used

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preparation example Construction

[0032] The invention provides a preparation method for modifying medical polyether ether ketone material with shellac mixed solution, comprising the following steps:

[0033] Step S1, polishing the surface of the polyether ether ketone material to a mirror surface;

[0034] Step S2, performing sulfonation treatment on the polyetheretherketone material polished to a mirror surface to obtain a three-dimensional porous polyetheretherketone material;

[0035] Step S3, preparing metal-organic framework (ZIF-8) powder and shellac solution into a shellac mixed solution containing ZIF-8;

[0036] Step S4, immersing the sulfonated polyether ether ketone in the shellac mixed solution, taking it out and drying it naturally to obtain a medical polyether ether ketone material modified by the shellac mixed solution.

[0037] The shellac mixed solution modified medical polyetheretherketone material prepared by the present invention is coated with a shellac solution mixed with a metal-organi...

Embodiment 1

[0056] (1) Grind and polish polyether ether ketone first, then ultrasonically clean it with acetone, ethanol, and deionized water three times respectively, and dry it at room temperature for later use.

[0057] (2) Immerse the smooth polyetheretherketone prepared in step (1) in the concentrated sulfuric acid solution, stir evenly for 30s, heat the obtained polyetheretherketone sheet in a water bath at a temperature of 60°C, and obtain sulfonated polyetheretherketone .

[0058] (3) Configure 0.1mol / L shellac solution.

[0059] (4) Configure ZIF-8 hydrothermal reaction solution A) to be 2-methylimidazole dissolved in NH 4 OH solution, stirred for 30min, the concentration of 2-methylimidazole was 1.8mol / L.

[0060] (5) Configure ZIF-8 hydrothermal reaction solution B): Zn(NO 3 ) 2 Dissolve in ultrapure water, stir for 30min, Zn(NO 3 ) 2 The concentration is 0.6mol / L.

[0061] (6) Quickly pour solution B in step (5) into solution A in step (4) and stir for 5 minutes and pla...

Embodiment 2

[0065] (1) Grind and polish polyether ether ketone first, then ultrasonically clean it with acetone, ethanol, and deionized water three times respectively, and dry it at room temperature for later use.

[0066] (2) Immerse the smooth polyether ether ketone prepared in step (1) in the concentrated sulfuric acid solution, stir evenly for 60 seconds, heat the obtained polyether ether ketone sheet in a water bath at a temperature of 90°C, and obtain sulfonated polyether ether ketone .

[0067] (3) Configure 0.2mol / L shellac solution.

[0068] (4) Configure ZIF-8 hydrothermal reaction solution A) to be 2-methylimidazole dissolved in NH 4 OH solution, stirred for 30min, the concentration of 2-methylimidazole was 1.8mol / L.

[0069] (5) Configure ZIF-8 hydrothermal reaction solution B): Zn(NO 3 ) 2 Dissolve in ultrapure water, stir for 30min, Zn(NO 3 ) 2 The concentration is 0.6mol / L.

[0070] (6) Quickly pour solution B in step (5) into solution A in step (4) and stir for 5 mi...

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Abstract

The invention provides a preparation method of a medical polyether-ether-ketone material modified by a lac mixed solution, and relates to the field of biological materials. The preparation method comprises the following steps of: immersing polyether-ether-ketone with a sulfonated surface into a lac solution mixed with a metal organic framework (ZIF-8), and standing at normal temperature to obtain a metal organic framework coating on the surface of the polyether-ether-ketone; sulfonating the surface of the polyether-ether-ketone, and combining the metal organic framework composite coating; and taking multiple pores of the sulfonated polyether-ether-ketone as anchoring points of the ZIF-8, and more tightly modifying the ZIF-8 on the surface of the polyether-ether-ketone through lac. The lac is a secretion of insects parasitized on plants, and has abnormal adhesive force on a common surface as a natural polymer. The ZIF-8 has antibacterial and osteogenic effects, so that the finally prepared composite coating has excellent antibacterial and osteogenic properties, and is a potential candidate for bone tissue engineering application.

Description

technical field [0001] The invention relates to the field of surface modification of medical polymer materials, in particular to a preparation method for modifying medical polyether ether ketone materials with shellac mixed solution. Background technique [0002] With the in-depth development of material science, cell biology and tissue engineering technology, biomedical materials are more and more widely used in the medical field. Biomedical materials are in contact with living systems, which can diagnose, treat, repair, replace and induce tissue regeneration on the damaged tissues and organs of organisms, so as to improve the functions of organisms without causing adverse reactions to their internal tissues. Special functional materials. With the development of society and economy, people have higher requirements for life, health and quality of life. Biomedical materials have received extensive attention and great development. The research and development of biomedical ma...

Claims

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Application Information

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IPC IPC(8): A61L27/34A61L27/28A61L27/18A61L27/56A61L27/58A61L27/54
CPCA61L27/34A61L27/28A61L27/18A61L27/56A61L27/58A61L27/54A61L2300/30A61L2300/404A61L2420/02A61L2420/06A61L2430/02C08L87/00C08L61/16
Inventor 肖天华郭元王簕周蕾娄爱菊刘松吴增晖
Owner THE THIRD AFFILIATED HOSPITAL OF GUANGZHOU MEDICAL UNIVERSITY
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