3-benzoyl dehydrotumulosic acid

A technology of methanol and compounds, applied in the field of monomer compounds, to achieve the effects of improving learning and memory ability, prolonging the latency period, and reducing the number of mistakes

Inactive Publication Date: 2011-09-14
BEIJING UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, I, according to the research literature report of Poria cocos chemical composition, there is no research report about 3-benzoyl dehydrotemoic

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0063] Example 1:

[0064] Take 1 kg of Poria medicinal materials, use 80% ethanol to heat and reflux for 3 times, combine the extracts, recover under reduced pressure until there is no alcohol, and centrifuge; take the supernatant and pass through the 3LAB-8 macroporous adsorption resin. Elute with 10L of 40% ethanol and 10L of 90% ethanol, combine the 90% ethanol eluate, recover the solvent, dry under reduced pressure, and combine with centrifugal precipitation to obtain dry extract I; take extract I and add methanol to reflux for extraction until extraction The liquid is nearly colorless, the extracts are combined, the solvent is recovered under reduced pressure, and dried under reduced pressure to obtain dry extract II; take extract II, add 200ml methanol to dissolve, stir in 500g silica gel, evaporate the solvent to obtain sample-mixed silica gel, take another 1.5Kg of blank silica gel, fully swelled with petroleum ether, wet-pack the column, and pack the sample-mixed silica...

Example Embodiment

[0065] Example 2:

[0066] Take 1kg of Poria medicinal materials, use 70% ethanol to heat and reflux for extraction twice, combine the extracts, recover under reduced pressure until there is no alcohol, and centrifuge; take the supernatant and pass through 2.5L AB-8 type macroporous adsorption resin, after the adsorption is over Eluted with 8L 30% ethanol and 12L 80% ethanol successively, combined the 80% ethanol eluate, recovered the solvent, dried under reduced pressure, and combined with the centrifugal precipitation to obtain dry extract I; take extract I and add methanol reflux extraction When the extract is almost colorless, combine the extracts, recover the solvent under reduced pressure, and dry under reduced pressure to obtain dry extract II; take extract II, add 200ml methanol to dissolve, stir in 400g silica gel, evaporate the solvent to obtain sample-mixed silica gel. Take another 1.8Kg of blank silica gel, add petroleum ether to fully swell it, and pack the column by...

Example Embodiment

[0067] Example 3:

[0068] Take 10kg of Poria medicinal materials, use 70% ethanol to heat and reflux for 3 times, combine the extracts, recover under reduced pressure until there is no alcohol, and centrifuge; take the supernatant and pass through 30LAB-8 type macroporous adsorption resin. Elute with 70L of 40% ethanol and 100L of 80% ethanol, combine the 80% ethanol eluates, recover the solvent, dry under reduced pressure, and combine with centrifugal precipitation to obtain dry extract I; take extract I and reflux with methanol to extract. The liquid is nearly colorless, the extracts are combined, the solvent is recovered under reduced pressure, and dried under reduced pressure to obtain dry extract II; take extract II, add 1500ml methanol to dissolve, stir in 2kg silica gel, evaporate the solvent to obtain sample-mixed silica gel; Blank silica gel 8Kg, after adding petroleum ether to fully swell, the column is wet packed, the sample-mixed silica gel is packed on the top of th...

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Abstract

The invention discloses a novel compound. The compound is 3-benzoyl dehydrotumulosic acid and has high anti-dementia activity.

Description

technical field [0001] The invention relates to a monomer compound and belongs to the field of chemical medicine. Background technique [0002] Poria cocos (Schw.) Wolf is the dry sclerotia of Poria cocos (Polyporaceae) fungus Poria cocos. Poria cocos is the first batch promulgated by the Ministry of Health. It is one of the 34 varieties that are both food and medicine according to tradition. Poria cocos is a species recorded in the Pharmacopoeia of the People's Republic of China. Its nature is flat, sweet and light. Guixin, lung, spleen, kidney channel. It has the effects of diuresis and dampness, invigorating the spleen and nourishing the middle, calming the mind and calming the nerves. Modern pharmacological studies have shown that Poria cocos has good [0003] The chemical composition of Poria cocos is relatively complex, including polysaccharides, triterpenes, fatty acids, sterols and enzymes. Polysaccharides and triterpenes are its main components. At present, I,...

Claims

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Application Information

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IPC IPC(8): C07J9/00
Inventor 石任兵姜艳艳刘洋王帅
Owner BEIJING UNIV OF CHINESE MEDICINE
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