Polyurethane material subjected to photo-induced graft surface modification by fungi polysaccharide and preparation method thereof

A technology of polyurethane materials and fungal polysaccharides, applied in the field of polyurethane materials and their preparation, can solve problems such as inflammatory reactions, achieve the effects of maintaining biological activity, improving biocompatibility, and maintaining biological functions

Inactive Publication Date: 2012-12-19
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, polyurethane materials are widely used in the field of biomedical materials. However, when they are implanted in the body for a long time as built-in medical devices, they often cause inflammation in the body.

Method used

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  • Polyurethane material subjected to photo-induced graft surface modification by fungi polysaccharide and preparation method thereof
  • Polyurethane material subjected to photo-induced graft surface modification by fungi polysaccharide and preparation method thereof
  • Polyurethane material subjected to photo-induced graft surface modification by fungi polysaccharide and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A kind of preparation method of the polyurethane material that adopts fungal polysaccharide photochemical grafting surface modification, it comprises following specific steps:

[0029] 1) Preparation of aromatic azides——4-azidobenzoic acid:

[0030] In a 250mL three-necked flask equipped with a thermometer, a stirrer and a dropping funnel, add 1.72g of 4-aminobenzoic acid, 50mL of distilled water and 5mL of 37wt% concentrated hydrochloric acid successively, stir at room temperature for 5 minutes, and wait for the reactants to dissolve Then placed in an ice-water bath and stirred for 1 hour. Then use the dropping funnel to add 5 mL of 0.19 g / mL sodium nitrite solution dropwise at a speed of 0.5 mL / min. Test the solution on the starch-potassium iodide test paper. If dark blue appears immediately, it indicates that the aqueous solution of sodium nitrite has been added in an appropriate amount and there is no need to add it dropwise. After the aqueous solution of sodium n...

Embodiment 2

[0043] A kind of preparation method of the polyurethane material that adopts fungal polysaccharide photochemical grafting surface modification, it comprises following concrete steps:

[0044] 1) Preparation of aromatic azides——4-azidobenzoic acid:

[0045] In a 500mL three-necked flask equipped with a thermometer, a stirrer and a dropping funnel, sequentially add 3.44g of 4-aminobenzoic acid, 100mL of distilled water and 10mL of 37wt% concentrated hydrochloric acid, and stir at room temperature for 10 minutes until the reactant dissolves Then placed in an ice-water bath and stirred for 1 hour. Then use the dropping funnel to add 10mL of 0.19g / mL sodium nitrite aqueous solution dropwise at a rate of 1mL / min. Check on the starch-potassium iodide test paper, if the dark blue color appears immediately, it means that the sodium nitrite has reached an appropriate amount and there is no need to add it dropwise. After the sodium nitrite was added dropwise, stirring was continued for...

Embodiment 3

[0054] A kind of preparation method of the polyurethane material that adopts fungal polysaccharide photochemical grafting surface modification, it comprises following specific steps:

[0055] 1) Preparation of aromatic azides——4-azidobenzoic acid:

[0056] In a 250mL three-necked flask equipped with a thermometer, a stirrer and a dropping funnel, add 1.72g of 4-aminobenzoic acid, 50mL of distilled water and 5mL of 37wt% concentrated hydrochloric acid successively, and stir at room temperature for 6 minutes. Place in an ice-water bath and stir again. Then use the dropping funnel to add 5 mL of 0.19 g / mL sodium nitrite solution dropwise at a speed of 0.5 mL / min. Test the liquid on the starch-potassium iodide test paper. If dark blue appears immediately, it indicates that the sodium nitrite has been added in an appropriate amount and no further addition is necessary. After the sodium nitrite was added dropwise, stirring was continued for 15 minutes. Then, use a dropping funnel...

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Abstract

The invention relates to a polyurethane material subjected to photo-induced graft surface modification by fungi polysaccharide and a preparation method thereof. The polyurethane material subjected to photo-induced graft surface modification by the fungi polysaccharide is characterized by consisting of a base material and a modification layer; the base material consists of a common commercial polyurethane material; and the modification layer is formed by performing photo-induced graft surface modification on the surface of the base material by using fungi polysaccharide, namely lentinan. The surface of the polyurethane material subjected to photo-induced graft surface modification by the fungi polysaccharide has high antibacterial activity, and blood compatibility, so that as the artificial transplant material implanted into a human body, and the biocompatible medical material of an artificial organ and device, the polyurethane material has a wide application range, and the preparationmethod of the material is simple, high in reaction speed, and low in cost and is easy to control.

Description

technical field [0001] The invention belongs to the fields of biomedical materials, macromolecule chemistry and photochemical reaction, and in particular relates to a polyurethane material surface-modified by photochemical grafting of fungal polysaccharides and its preparation and application. Background technique [0002] At present, polyurethane materials are widely used in the field of biomedical materials. However, when they are implanted in the body for a long time as built-in medical devices, they often cause inflammation in the body. Therefore, it is of great significance to further improve the surface properties of polyurethane biomedical materials and modify the surface. Photochemical grafting is a method of coupling components or biomolecules with specific properties to the surface of a material using ultraviolet or visible (300-800nm) light, using chemical linking components with thermally active groups and photoactive groups . The main advantage of this method ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08J7/12C08L75/04C08J5/18C08G81/00C08B37/00
Inventor 王艺峰姚祥雨陈筠熊燕飞陈艳军
Owner WUHAN UNIV OF TECH
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