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Preparation method of ginsenoside Rg1 injection preparation

A technology for injection preparations and ginsenosides, which is applied in the field of medicine and can solve the problems of unprepared ginsenoside Rg injection preparations and complex physical and chemical properties of ginsenoside Rg

Inactive Publication Date: 2011-11-09
PHARMA RES INST OF BENCAO TIANYUAN OF BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Ginsenoside Rg 1 Injections are expected to become innovative drugs, but ginsenoside Rg 1 The physical and chemical properties are very complicated, and it needs to be determined through a large number of creative experiments to prepare it into an injection preparation. After consulting the literature, there is no preparation of ginsenoside Rg 1 A detailed report on the study of injectable preparations

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] A kind of ginsenoside Rg 1 The preparation method of injection preparation, take ginsenoside Rg 1 , add water for injection to dissolve completely, add activated carbon for adsorption, filter, add water for injection to the filtrate to make the solution ginsenoside Rg 1 The concentration is 5mg / ml, add pH regulator sodium hydroxide to make the pH of the solution 7.0, sterilize at 121°C for 30 minutes, and prepare water injection according to the conventional preparation method of water injection.

Embodiment 2

[0057] A kind of ginsenoside Rg 1 The preparation method of injection preparation, take ginsenoside Rg 1 , add water for injection to dissolve completely, add activated carbon for adsorption, filter, add water for injection to the filtrate to make the solution ginsenoside Rg 1 The concentration is 20mg / ml, and the pH regulator potassium hydroxide is added to make the pH of the solution 8.5, sterilized at 121°C for 30 minutes, and prepared into water injection according to the conventional preparation method of water injection.

Embodiment 3

[0059] A kind of ginsenoside Rg 1 The preparation method of injection preparation, take ginsenoside Rg 1 , add water for injection to dissolve completely, add activated carbon for adsorption, filter, add water for injection to the filtrate to make the solution ginsenoside Rg 1 The concentration is 10mg / ml, and the pH regulator potassium bicarbonate is added to make the pH of the solution 8.0, sterilized at 115°C for 60 minutes, and prepared into water injection according to the conventional preparation method of water injection.

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PUM

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Abstract

The invention belongs to the field of medical technologies, and discloses a preparation method of a ginsenoside Rg1 injection preparation. The method is characterized in that: a basis of ginsenoside Rg1 physical and chemical properties is combined with injection preparation research methods; during the preparation of the injection (a liquid drug injection, a powder injection, or a lyophilized powder injection), the concentration and the pH value of the preparation are regulated to proper values, such that the product quality is ensured. A stability experiment shows that, the injection preparation prepared with the method provided by the present invention has an excellent stability.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a kind of ginsenoside Rg 1 Preparation method of injection preparation. Background technique [0002] Ginsenoside Rg 1 It is mainly derived from the roots, stems, leaves, and flower buds of plants such as Araliaceae Panax ginseng, Panax notoginseng, American ginseng, Vietnamese ginseng, bamboo joints, Cucurbitaceae Gynostemma genus Gynostemma, Yuanguo Gynostemma, etc. It has good pharmacological activity: (1) Protective effect on myocardial ischemia-reperfusion, studies have shown that ginsenoside Rg 1 It can reduce the injury of myocardial ischemic cells in SD neonatal mice, and exert a protective effect on myocardial ischemia-reperfusion; (2) the protective effect on cerebral ischemia, ginsenoside Rg 1 Can increase cerebral blood flow by improving animal microcirculation, play the effect of improving cerebral ischemia; (3) have antithrombotic effect, ginsenoside Rg 1 Can s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/704A61P9/10A61P7/02A61P35/00A61P39/00A61P7/08
Inventor 顾群郭小鹏孙德杰渠守峰
Owner PHARMA RES INST OF BENCAO TIANYUAN OF BEIJING