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Chemical composition for target imaging

A chemical composition and imaging technology, which is used in preparations for in vivo experiments, contrast agents for nuclear magnetic resonance/magnetic resonance imaging, radioactive preparations in vivo, etc.

Inactive Publication Date: 2011-11-09
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Also, although extensive clinical and preclinical studies have been carried out with different Y molecules, there is a major disadvantage: it is a pure beta emitter and therefore In must be used as a "matching pair for imaging, biodistribution and evaluation of dosimetry". pair) "substitute

Method used

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  • Chemical composition for target imaging
  • Chemical composition for target imaging
  • Chemical composition for target imaging

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Embodiment Construction

[0023] In order to make the above-mentioned purposes, features and advantages of the present invention more obvious and understandable, the preferred embodiments of the present invention are specifically cited below, and are described in detail as follows:

[0024] As used herein, "a" includes the singular and the plural and means one or more than one. By way of example, "a ligand" means one ligand or more than one ligand.

[0025] In the field of nuclear medicine, specific pathological conditions are localized, or their extent assessed, by detecting the distribution of small amounts of internally administered radiolabeled tracer compounds, called radiotracers or radiopharmaceuticals. Methods of detecting such radiopharmaceuticals are generally known as contrast or radiographic methods.

[0026] "Alkyl" refers to a saturated aliphatic hydrocarbon, which includes straight chain, branched chain and cyclic alkyl groups. Alkyl groups may contain any combination of acyclic and cy...

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Abstract

The invention discloses a chemical composition for target imaging, which is used in the fields of radiation chemistry, nuclear imaging, radionuclide therapy and chemosynthesis and comprises TA2S derivatives which can be conjugated with a therapeutic or diagnostic ligand and can be chelated with metal under certain conditions.

Description

【Technical field】 [0001] The present invention relates to a chemical composition for target imaging, in particular to a chemical composition for target imaging in the fields of radiochemistry, nuclear imaging, radionuclear seed therapy and chemical synthesis. 【Background technique】 [0002] Diagnostic imaging techniques such as computed tomography (CT) and magnetic resonance imaging (MRI) provide anatomical information about disease sites. Although these modalities are commonly used to monitor changes in tumor size, they cannot assess functional changes occurring in cells or tumors. Accordingly, functional imaging techniques such as positron emission tomography (PET) and single photon emission computed tomography (SPECT) have experienced a boom due to advances in molecular imaging techniques. Novel molecular imaging targets for diagnosis and therapy have been developed to visualize disease states and pathological processes without surgical exploration of the body. In parti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K49/00A61K49/06A61K51/00A61K103/10
Inventor 尤文正
Owner 尤文正
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