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Anti-wrinkle cosmetic skin composition containing leontopodic acid as an active ingredient

A technology of active ingredients and compositions, which is applied in the field of skin cosmetic compositions for wrinkle improvement containing edelweiss acid as an active ingredient, which can solve the problems of reducing normal skin functions, unsatisfactory effects, and skin side effects, and achieve the improvement of collagenase Excellent expression inhibition effect, excellent acceleration effect, dosage form stability, and excellent absorption ability of hard skin

Active Publication Date: 2011-11-09
AMOREPACIFIC CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, excessive physical stimulation, chemical stimulation, fatigue, and lack of nutrition from the outside will reduce the normal function of the skin and promote skin aging such as loss of elasticity, keratinization, and wrinkles. In order to prevent these phenomena and maintain health Most of the currently used cosmetics have many problems such as unsatisfactory effects or skin side effects.

Method used

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  • Anti-wrinkle cosmetic skin composition containing leontopodic acid as an active ingredient
  • Anti-wrinkle cosmetic skin composition containing leontopodic acid as an active ingredient
  • Anti-wrinkle cosmetic skin composition containing leontopodic acid as an active ingredient

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] [embodiment 1] the manufacture of edelweiss acid

[0051] The extract of Edelweiss alpine (2 kg) dried at room temperature in a cool place was collected and concentrated under reduced pressure to obtain 160.5 g of methanol extract by repeating the cold-extraction with methanol three times every other week. The methanol extract was suspended in distilled water and partitioned with hexane (25.2 g), then the remaining aqueous layer was partitioned with ethyl acetate to obtain the acetonitrile fraction (20.4 g), and the remaining aqueous layer was partitioned with butanol Whereas the butanol extract (20.6 g) and finally the water division 40.6 g were obtained.

[0052] Then, utilize the glass column ( 7734, Merck Company) and a mixed solvent of water, acetonitrile, and methanol to dissolve the active substance to obtain a 10-minute division. Among them, sub-hollow column chromatographic analysis was carried out on the small division 7 (1.153g) containing the surface mate...

Embodiment 2

[0053] [Embodiment 2] Manufacture is stable into the edelweiss acid of nano liposome

[0054] In order to stabilize the above-mentioned edelweiss acid into nanoliposomes, mix 580 g of glycerin, 200 g of caprylic triglyceride, 50 g of phospholipids, and 20 g of cholesterol, stir with a mixer and heat to 75°C to mix and dissolve, then add 1 The edelweiss acid solid powder 50g that obtains and it is dissolved completely. Here, 100 g of purified water was slowly added and mixed, and then passed through a high-pressure softening device (Microfluidizer M210EH, Microfluidics, USA) 3 three times under the regulation of 50° C. and 1000 mbar pressure to produce nanoliposomes of edelweisin. The particle size of this liposome is about 70 nm.

experiment example 1

[0055] [Experimental Example 1] Detection of the promotion effect of collagen biosynthesis

[0056] Compared with tocopherol and EGCG, which can promote collagen biosynthesis, the collagen biosynthesis promoting effect of the above-mentioned Example 1 was detected.

[0057] First, seeding (seeding) 10 per well in 24 wells 5 Human fibroblasts (PromoCell, Germany) were grown to 90%. Then it was cultured with serum-free DMEM medium for 24 hours, and the embodiment 1 melted in serum-free medium, tocopherol and EGCG were respectively treated with 10-4 molar concentration and in CO 2 Incubate in an incubator for 24 hours. The upper layer of these liquids was salvaged and checked for the increase or decrease of procollagen by using procollagen type (I) enzyme-linked immunosorbent assay (ELISA) tool (procollagen type (I)). The results are shown in Table 1 below, where the synthesis ability was compared with the non-treated group as 100.

[0058] 【Table 1】

[0059] proces...

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Abstract

Disclosed is an anti-wrinkle cosmetic skin composition containing leontopodic acid as an active ingredient, which exhibits improved collagenase expression inhibitory effects, collagen biosynthesis stimulating effects, and anti-wrinkle effects. Further, the present invention discloses an anti-wrinkle cosmetic skin composition which contains leontopodic acid stabilized with a nanoliposome, and which is excellent in formulation stability and transdermal delivery.

Description

technical field [0001] The present invention relates to a compound containing edelweiss acid {Leontopodicacid; 2-[(3S)-3-hydroxybutanate]-3,4,5-tris-[(2E)-3-( 3,4-dihydroxyphenyl)-2-propenoate]-D-glucaricacid} skin cosmetic composition for improving wrinkles. [0002] [chemical formula 1] [0003] Background technique [0004] The skin is the first protective membrane of the human body. It protects various organs in the body from external environmental stimuli such as temperature and humidity changes and ultraviolet rays and pollutants. It also plays an important role in maintaining the homeostasis of organisms such as regulating body temperature. However, excessive physical stimulation, chemical stimulation, fatigue, and lack of nutrition from the outside will reduce the normal function of the skin and promote skin aging such as loss of elasticity, keratinization, and wrinkles. In order to prevent these phenomena and maintain health And there are many problems such as ...

Claims

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Application Information

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IPC IPC(8): A61K8/35A61Q19/08
CPCA61Q19/08A61K8/14A61K8/375A61K8/55A61K8/66A61Q19/00A61Q19/02
Inventor 金汉星安顺爱金德姬金真雄金汉坤
Owner AMOREPACIFIC CORP
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