New application of ilex pubescens extract in preparing medicines for enhancing cerebral ischemia resistance
A technology of holly holly and extract, applied in the field of medicine, to achieve the effect of improving cerebral ischemia tolerance, easy preparation, and simple method
Inactive Publication Date: 2012-10-03
HENAN UNIV OF CHINESE MEDICINE
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However, there has been no public report on the preparation of drugs for improving cerebral ischemia tolerance with the extract of Ilex pubescens
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[0009] The embodiments of the present invention will be described in detail below in combination with specific situations.
[0010] When the present invention is concretely implemented, at first prepare the extract of Ilex pubescens, the method is, Ilex pubescens is pulverized into dry medicine powder, and the mass concentration of 8 times of weight is added to the medicine powder and is 70% ethanol (also known as 70% ethanol, hereinafter the same), Heat and reflux 2 times, each time for 1 hour, filter, combine the filtrate, reclaim ethanol and concentrate to a concentrated solution with a relative density of 1.10 to 1.20 at 50°C, and the concentrated solution is dispersed with water (or called dilution) to become the weight volume of Ilex pubescens (w / v) medicinal liquid (medicinal material: medicinal liquid = 1: 1), the weight and volume refer to the g meter of Ilex pubescens and the ml meter of the medicinal liquid. Liquid ultrafiltration to obtain the extract of Ilex pube...
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The invention relates to new application of an ilex pubescens extract in preparing medicines for enhancing cerebral ischemia resistance, which can effectively solve the problem of preparation of medicines for enhancing cerebral ischemia resistance so as to enhance the cerebral ischemia resistance. The technical scheme for solving the problem comprises the following steps: pulverizing ilex pubescens into dried medicinal powder, refluxing with ethanol twice, merging the filtrates, concentrating, dispersing with water to obtain a medicinal liquor, standing the medicinal liquor, filtering, and centrifugalizing to obtain an ilex pubescens extracting solution; and passing the ilex pubescens extracting solution through polyamide columns, eluting with ethanol and sodium carbonate water solution, regulating the pH value to neutral, concentrating under reduced pressure, drying and pulverizing to obtain the ilex pubescens extract, wherein the mass content of the general flavone (rutin) in the extract is at least 54.0%. The invention has the advantage of simple method, and is easy to prepare; the ilex pubescens extract general flavone can be effectively used for preparing medicines for enhancing cerebral ischemia resistance; and the invention provides new application of the ilex pubescens extract, enhances the new medicinal value of ilex pubescens, and is an innovation in traditional Chinese medicines.
Description
technical field [0001] The invention relates to the field of medicine, in particular to a new application of a holly holly extract in the preparation of drugs for improving cerebral ischemia tolerance. Background technique [0002] Ilex pubescens is the dry root of Ilex pubescens Hook.et Arn., a plant of the genus Ilex in the Ilex family. It grows in the bushes on the hillside. It has the effects of promoting blood circulation, removing swelling and relieving pain, clearing away heat and detoxification, and is widely used in the treatment of coronary heart disease and angina pectoris. And vasculitis, central retinitis, tonsillitis, pharyngitis, pneumonia in children, etc., has a good curative effect, and scholars at home and abroad have widely paid attention to it. In recent years, it has been found that Mao Dongqing plays an important role in the treatment of cardiovascular and cerebrovascular diseases. Mao Dongqing has a protective effect on cerebrovascular and has a certa...
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IPC IPC(8): A61K31/7028A61K36/185A61P9/10A61K125/00
Inventor 苗明三白明方晓燕
Owner HENAN UNIV OF CHINESE MEDICINE