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Application of gsk3 inhibitor in preparation of medicine for treating hyperandrogenism

A technology of hyperandrogenemia and inhibitor, applied in the field of biomedicine, can solve the problems of lowering androgen, lowering androgen level of patients, etc.

Inactive Publication Date: 2011-11-30
吴效科
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] On the basis of a large number of clinical trials, the present invention finds that GSK3 inhibitors can reduce the level of androgen in patients. At present, there is no report about the reduction of androgen by GSK3 inhibitors.

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  • Application of gsk3 inhibitor in preparation of medicine for treating hyperandrogenism

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Experimental program
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Embodiment 1

[0015] Materials and Methods:

[0016] 1. Research object

[0017] A total of 17 infertile women who received in vitro fertilization / intracytoplasmic sperm injection-embryo transfer (IVF / ICSI-ET) treatment in the Reproductive Center of the First Affiliated Hospital of Harbin Medical University from November 2009 to April 2010 were selected. Divide into two groups.

[0018] 1.1 Hyperandrogenemia group (experimental group): A total of 7 patients with hyperandrogenemia who received IVF / ICSI-ET treatment in the Reproductive Center of the First Affiliated Hospital of Harbin Medical University from November 2009 to March 2010 were selected. Age 29.29 ± 1.9 years old.

[0019] 1.2 Control group: randomly select 10 infertile patients who received IVF / ICSI-ET treatment in the reproductive center at the same time, regular menstruation, infertility caused by fallopian tube factors, and basic blood (on the third day of menstruation) FSH, LH, E2, T and prolactin (PRL) were within the no...

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Abstract

The invention discloses the use of GSK3 inhibitors in the preparation of drugs for the treatment of hyperandrogenism, especially the use of SB415286, a specific inhibitor of GSK3β, in the preparation of drugs for the treatment of hyperandrogenism. The invention also provides a method for the treatment of hyperandrogenism A pharmaceutical composition for hyperandrogenism, comprising a therapeutically effective dose of the GSK3 inhibitor according to claim 1 or 2 and a pharmaceutically acceptable carrier. The use of the GSK3 inhibitor disclosed in the present invention in the preparation of a drug for treating hyperandrogenism is characterized in that when the dose of the GSK3 inhibitor is 5 μmol, the best therapeutic effect can be achieved.

Description

technical field [0001] The invention relates to the application of a GSK3 inhibitor in the preparation of therapeutic drugs, in particular to its application in the preparation and treatment of hyperandrogenism, belonging to the field of biomedicine. Background technique [0002] Androgen is a very important hormone in the physiological process of female reproduction, which is the precursor of estrogen synthesis for ovaries, especially follicles. In the follicular phase of a normal menstrual cycle, the average serum testosterone concentration is 0.43ng / ml, and the upper limit is 0.68ng / ml. If it exceeds 0.7ng / ml (equal to 2.44nmol / L), it is called hypertestosteroneemia, or hyperandrogen blood disease. The level of androgen in female blood is too high and its activity is enhanced, which is a common gynecological endocrine disorder. Clinically, the drugs used to treat hyperandrogenism mainly include oral contraceptives, progestins, gonadotropin-releasing hormones, glucocorti...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K31/4015A61P5/28
Inventor 吴效科桑敏马红丽
Owner 吴效科