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Preparation technology and production method of a new integrated dosage form of Xiebai powder

A production method and new dosage form technology, applied in the field of Xiebai San integrated new dosage form preparation, to achieve the effect of strong slow and controlled release performance and wide target distribution

Inactive Publication Date: 2011-12-21
SUZHOU ZHIWEITANG BIOLOGICAL TECH +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Due to too many chemical components, the chemical reaction of compound decoction of traditional Chinese medicine has not yet been revealed its mysterious veil, but some mysterious black boxes of medicinal effects in traditional Chinese medicine prescriptions are hidden in the decoction of traditional Chinese medicine. Traditional Chinese medicine is modernized and only uses monomers and effective parts

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] Prepare the following raw materials by the aforementioned method:

[0039] Extracts, nanoparticles, microcapsules, nanoparticles.

[0040] The composition of the raw materials used to make the active ingredients is——

[0041] Digupi 30 parts, Morus alba 30 parts, Zhi Licorice 6 parts.

[0042] Its manufacturing process is as follows:

[0043] In the GMP10000 clean room, the extract, nanoparticles, microcapsules, and nanoparticles are mixed according to the ratio of 4:2:2:2, and the standards for hard capsules in the first part of the "Chinese Pharmacopoeia" of the 2010 edition are adopted, and no excipients are added. , preservatives, using a fully automatic capsule filling machine to fill hard capsules to make hard capsules. Then carry out internal and external packaging such as counting, bottling, sealing, pasting labels, coding, and packing. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report.

Embodiment 2

[0045] Prepare the following raw materials by the aforementioned method:

[0046] Water decoction concentrate, nano liposome, nanoemulsion, microemulsion.

[0047] The composition of the raw materials used to make the active ingredients is——

[0048] Digupi 30 parts, Morus alba 30 parts, Zhi Licorice 6 parts.

[0049] Its manufacturing process is as follows:

[0050] In the GMP10000 clean room, the decoction concentrate, nanoliposome, nanoemulsion, and microemulsion were mixed in a ratio of 4:2:2:2, and the standards for some soft capsules in the first part of the "Chinese Pharmacopoeia" of the 2010 edition were used. , without adding auxiliary materials and preservatives, the soft capsules are made into soft capsules by using a fully automatic soft capsule filling machine. Then carry out internal and external packaging such as counting, bottling, sealing, labeling, coding, and packing. Finally, according to the production batch uniform instant sterilization, and issue a s...

Embodiment 3

[0052] Prepare the following raw materials by the aforementioned method:

[0053] Extract, nanoparticle, nanoemulsion.

[0054] The composition of the raw materials used to make the active ingredients is——

[0055] Digupi 30 parts, Morus alba 30 parts, Zhi Licorice 6 parts.

[0056] Its manufacturing process is as follows:

[0057] In the GMP10000 clean room, after mixing the extract, nanoparticles, and nanoemulsions in a ratio of 4:3:3, the 2010 edition of the "Chinese Pharmacopoeia" Part I of the film preparation standard is adopted, and the film-forming material is polyvinyl alcohol. film former. Cartoning, sealing, sticking labels, printing codes, packing and other internal and external packaging. Finally, according to the production batch uniform instant sterilization, and issue a sterilization report. The size of each film is 2-40 square centimeters, and each film is applied for 12-72 hours. The application site: neck, chest, back, abdomen, legs, soles of the feet, ...

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Abstract

The invention relates to a preparation technology and a production method of a new integrated dosage form of Xiebai powder. The raw material composition of the active ingredients is as follows: 30 parts of digu cortex, 30 parts of mulberry cortex and 6 parts of roasted licorice. Its production process includes: supersonic jet pulverization, alcohol water extraction, ultrasonic pulverization and extraction, water decoction and concentration, supersonic spray drying, nano grinding, high pressure emulsification, nano particle preparation, etc. The invention pays attention to the advantages of multi-synergy and multi-targeting embodied by the combination technology of nano-carriers. After large-scale production, the production cost can be greatly reduced, the product quality can be greatly improved, and the targeting and sustained release of the drug can be strengthened. It can be administered both internally and externally, and can be taken in four time periods according to the meridian flow and the flow of blood in the human body. Film-forming agents and transdermal agents can also be prepared and pasted on different parts of the human body according to the meridian flow and the flow of human Qi and blood, and can be directly absorbed through the skin.

Description

technical field [0001] The invention relates to a preparation technology of a new integrated dosage form of Xiebai powder, and also relates to a preparation technology of a new integrated dosage form of Xiebai powder and a production method thereof. Background technique [0002] Due to too many chemical components, the chemical reaction of compound decoction of traditional Chinese medicine has not yet been revealed its mysterious veil, but some mysterious black boxes of medicinal effects in traditional Chinese medicine prescriptions are hidden in the decoction of traditional Chinese medicine. Traditional Chinese medicine is modernized and only uses monomers and effective parts. Chinese herbal decoction concentrate cannot be discarded! When the traditional Chinese medicine prescription is decocted in water, due to the high temperature when the prescription is decocted together and the complex chemical environment in the solution, complexation, hydrolysis, oxidation, reductio...

Claims

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Application Information

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IPC IPC(8): A61K36/815A61K9/00A61P11/00A61P11/06A61P11/14A61P31/14
Inventor 杨洪舒
Owner SUZHOU ZHIWEITANG BIOLOGICAL TECH
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